Molecules, Vol. 24, Pages 2: Wound Healing Effect of Essential Oil Extracted from Eugenia dysenterica DC (Myrtaceae) Leaves

Molecules, Vol. 24, Pages 2: Wound Healing Effect of Essential Oil Extracted from Eugenia dysenterica DC (Myrtaceae) Leaves Molecules doi: 10.3390/molecules24010002 Authors: Sandra Márcia Mazutti da Silva Claudio Rodrigues Rezende Costa Guilherme Martins Gelfuso Eliete Neves Silva Guerra Yanna Karla de Medeiros Nóbrega Sueli Maria Gomes Aline Pic-Taylor Yris Maria Fonseca-Bazzo Damaris Silveira Pérola de Oliveira Magalhães The use of natural oils in topical pharmaceutical preparations has usually presented safe agents for the improvement of human health. Based on research into the immense potential of wound management and healing, we aimed to validate the use of topical natural products by studying the ability of the essential oil of Eugenia dysenterica DC leaves (oEd) to stimulate in vitro skin cell migration. Skin cytotoxicity was evaluated using a fibroblast cell line (L929) by MTT assay. The oil chemical profile was investigated by GC-MS. Moreover, the inhibition of lipopolysaccharide (LPS) induced nitric oxide (NO) production in the macrophage cell line (RAW 264.7) tested. The Chick Chorioallantoic Membrane (CAM) assay was used to evaluate the angiogenic activity and irritating potential of the oil. The oEd induces skin cell migration in a scratch assay at a concentration of 542.2 µg/mL. α-humulene and β-caryophyllene, the major compounds of this oil, as determined by GC-MS, may partly explain the mig...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research