In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives

Plasmodium falciparum has shown multidrug resistance, leading to the necessity for the development of new drugs with novel targets, such as the synthesis of isoprenic precursors, which are excellent targets becau...

Source: Malaria Journal - December 19, 2018 Category: Infectious Diseases Authors: Valeska S. de Sena Pereira, Fl ávio da Silva Emery, Lis Lobo, Fátima Nogueira, Jonas I. N. Oliveira, Umberto L. Fulco, Eudenilson L. Albuquerque, Alejandro M. Katzin and Valter F. de Andrade-Neto Tags: Research Source Type: research