Hydrocortisone muco-adhesive buccal tablets

Hydrocortisone muco-adhesive buccal tablets should not be used off-label for treating adrenal insufficiency in children due to serious risks. There is a risk of insufficient cortisol absorption and li
Source: Royal Pharmaceutical Society News - Category: Drugs & Pharmacology Source Type: news

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AbstractPurposeThe aim of this study was to identify and characterize immune checkpoint inhibitors (ICIs)-associated pituitary adverse events (AEs).MethodsThis is a retrospective disproportionality study based on VigiBase, the World Health Organization (WHO) global database of individual case safety reports (ICSRs), with a study period from January 1, 2011 to March 6, 2019. Information component (IC) and reporting odds ratio (ROR) are measures of disproportionate analysis. IC was used to evaluate the association between ICIs and pituitary AEs, while ROR was used to evaluate the differences in reporting of pituitary AEs bet...
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Authors: Grassi G, Morelli V, Ceriotti F, Polledri E, Fustinoni S, D'Agostino S, Mantovani G, Chiodini I, Arosio M Abstract PURPOSE: The current cut-offs for the diagnosis of adrenal insufficiency (AI) have been established using outdated immunoassays. We compared the cortisol concentrations measured with Roche Cortisol I (R1), the newly available Roche Cortisol II (R2), and liquid chromatography tandem mass spectrometry (LC-MS/MS), the gold standard procedure to measure steroids in patients undergoing the corticotropin (ACTH) test. METHODS: We enrolled 30 patients (age 47 ± 21 years) ...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Condition:   Adrenal Insufficiency, Congenital Interventions:   Other: Continuous blood glucose measurement;   Other: Measurement of capillary blood glucose Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract When initiating growth hormone replacement therapy, it is important to consider a patient's other pituitary hormone replacement medications, as adjustments are often necessary. Growth hormone therapy can increase the metabolism of hydrocortisone or endogenous cortisol, unmasking borderline ACTH deficiency and leading to the development of adrenal insufficiency and adrenal crisis. In addition, growth hormone can enhance the metabolism of thyroxine to triiodothyronine, uncovering borderline TSH deficiency. In many patients, thyroid hormone replacement therapy must be started, or the dose of levothyroxine mu...
Source: Growth Hormone and IGF Research - Category: Endocrinology Authors: Tags: Growth Horm IGF Res Source Type: research
To keep patients with adrenal insufficiency safe during the COVID-19 crisis NHSE&I have agreed it is appropriate to release theNHS Emergency Steroid Card as a PDF that patients can download themselves.Guidance related to the release of the new NHS Emergency Steroid Card is almost ready for publication but the COVID-19 crisis has taken precedence.The card can be downloaded from ouradrenal crisis webpage, where you will also find additional emergency adrenal insufficiency management information and COVID-19 guidance.   
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
CONCLUSIONS: There are currently limited trials comparing the efficacy and safety of different glucocorticoid replacement regimens for treating 21-hydroxylase deficiency CAH in children and adults and we were unable to draw any firm conclusions based on the evidence that was presented in the included trials. No trials included long-term outcomes such as quality of life, prevention of adrenal crisis, presence of osteopenia, presence of testicular or ovarian adrenal rest tumours, subfertility and final adult height. There were no trials examining a modified-release formulation of HC or use of 24-hour circadian continuous sub...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Primary adrenal insufficiency, a potentially life-threatening disease, often runs an insidious course mandating a strong clinical suspicion for a prompt diagnosis.1 A 65-year-old farmer presented with a one-month history of fatigue and dizziness reporting episodes of loss of consciousness. On clinical examination, he appeared cachectic, with skin and mucosal hyperpigmentation. Chest computed tomography, subsequent to a chest X-ray showing a “coin” lesion, demonstrated a 2.4 × 2cm nodule of the posterior right upper lobe and small lymph-nodes in the mediastinum.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: CLINICAL COMMUNICATION TO THE EDITOR Source Type: research
In conclusion, the incidence of AI among NSCLC patients treated with anti-PD-1 antibodies was similar to previous studies. Corticosteroid replacement improved PS, symptoms, and laboratory data of patients with AI and suspicious of AI. Corticosteroid replacement may contribute to continuation of anti-PD-1 antibodies and survival outcome was preferable in patients with AI and suspicious of AI receiving corticosteroid treatment.
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research
The spring issue of the Society’s quarterly magazineThe Endocrinologist is now available online.  This issue, with the theme,'Exercise: It's good to move it, move it' examines multiple benefits of staying active, including maintaining a healthy metabolism, improving bone health and staying well during aging and pregnancy.In Society News, find out all you ever wanted to know about your new Society President, Raj Thakker, learn about the Society's new Undergraduate Video Award, and read new Society guidance on peri-operative management of adrenal insufficiency.Browse this latest issue, an...
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Isabelle Bourdeau Mitotane is a steroidogenesis inhibitor and adrenolytic drug used for treatment of adrenocortical cancer (ACC). Mitotane therapy causes adrenal insufficiency requiring glucocorticoid replacement in all patients. However, it is unclear whether chronic therapy with mitotane induces complete destruction of zona fasciculata and whether hypothalamic-pituitary-adrenal (HPA) axis can recover after treatment cessation. Our objective was to assess the HPA axis recovery in a cohort of patients after cessation of adjuvant mitotane therapy for ACC. We retrospectively reviewed patient files with stage I-II-III ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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