Evolution of Precision Treatments for Prostate Cancer

The concept of Precision Therapy in Prostate Cancer treatment will need to rely more heavily on genetic testing Author: vhsimons Added: 12/17/2018
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts

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ConclusionsThe cGrade is a simple Pca grade modification with better discriminative values for DSS and MFS than the GG, particularly impacting decision making in men with current GG2 Pca.Patient summaryMicroscopic grading is an important factor for decision making in prostate cancer (Pca) patients. We show that a simple grade modification better predicts Pca outcome and might improve treatment choices.
Source: European Urology - Category: Urology & Nephrology Source Type: research
Authors: Chen Y, Jiang X, Liu R, Zhang Z, Luo F, Qi S, Xu Y Abstract BACKGROUND Although magnetic resonance imaging (MRI)-targeted biopsy and saturation biopsy can improve the accuracy of prostate biopsy, transrectal ultrasound (TRUS)-guided prostate biopsy is still the cornerstone for diagnosis of prostate cancer. However, it is not clear whether it is necessary to perform the same TRUS-guided biopsy scheme for patients with different prostate specific antigen (PSA) or prostate specific antigen density (PSAD) levels. The purpose of this study was to evaluate the optimal core number for specific suspected prostate ...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Conditions:   Prostate Cancer;   Androgen Deprivation Therapy Intervention:   Behavioral: Walking football training Sponsors:   Associacao de Investigacao de Cuidados de Suporte em Oncologia;   Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.;   University of Beira Interior;   Federação Portuguesa de Futebol;   University Institute of Maia;   Câmara Municipal de Gaia Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Balacescu O, Crisan N, Balacescu L, Visan S, Tudoran O, Fetica B, Bungardean C, Marian C, Petrut B Abstract PURPOSE: To evaluate if a blood panel of genes involved in the modulation of the immune system, angiogenesis and tumor development could be used for prostate cancer detection. METHODS: Gene expression profiling of blood samples was assessed with the human angiogenesis RT² Profiler™ pcr array. The study group was divided into training and a testing/validation set. In total, 36 blood samples from 6 heatlhy men, 19 patients with prostate cancer (PCa) and 11 patients with benign prostate p...
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
Authors: Hu Y, Hong Z, Cheng C, Xu J Abstract PURPOSE: To investigate the effect and molecular mechanism of miR-490 in prostate cancer. METHODS: qRT-PCR was used to detect the expression of miR-490 in human prostate cancer PC-3 cell line (the control group B) and normal human prostate cells (the control group A), the overexpression vector (the positive group) and human prostate cancer PC-3 cells transfected by negative control (the negative group) were built, and the results of the transfection were detected by qRT-PCR. RESULTS: The relative expression levels of miR-490 in the cells in the control group A, ...
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
PROSTATE cancer is the most common cancer in men in the UK. It usually develops slowly. Early diagnosis is key to surviving prostate cancer - spotting the warning signs could save a person ’s life.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Despite recent therapeutic advances, prostate cancer remains a leading cause of cancer-related death. A subset of castration-resistant prostate cancers become androgen receptor (AR) signaling independent and develop neuroendocrine prostate cancer (NEPC) features through lineage plasticity. These NEPC tumors, associated with aggressive disease and poor prognosis, are driven, in part, by aberrant expression of N-Myc, through mechanisms that remain unclear. Integrative analysis of the N-Myc transcriptome, cistrome, and interactome using in vivo, in vitro, and ex vivo models (including patient-derived organoids) identified a l...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Cell Death &Disease, Published online: 20 August 2019; doi:10.1038/s41419-019-1861-1The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer
Source: Cell death and disease - Category: Internal Medicine Authors: Source Type: research
The objective of this study was to characterize the population pharmacokinetics of apalutamide and its metaboliteN-desmethyl-apalutamide in healthy male and castration-resistant prostate cancer subjects.MethodsPlasma concentration data for apalutamide and N-desmethyl-apalutamide from 1092 subjects (seven clinical studies) receiving oral apalutamide (30 –480 mg) once daily were pooled for a population pharmacokinetic analysis using a non-linear mixed-effect modelling approach. The impact of clinically relevant covariates was also assessed.ResultsApalutamide absorption was rapid, and the apparent steady-state volu...
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
Condition:   Prostate Cancer Interventions:   Other: Tissue donation;   Other: Blood Donation;   Other: Urine Donation;   Other: Healthcare data linkage Sponsors:   University College, London;   Medical Research Council;   Cancer Research UK;   Imperial College London;   King's College London Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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