Analgesic Effects of Hydromorphone versus Buprenorphine in Buprenorphine-maintained Individuals

Conclusions In this acute clinical pain model, high doses of IV hydromorphone (16 to 32  mg) were most effective in achieving analgesia but also displayed higher abuse liability and more frequent adverse events. Cold pressor testing was the most consistent measure of opioid-related analgesia.
Source: Anesthesiology - Category: Anesthesiology Source Type: research