Centers of excellence or excellence networks: The surgical challenge and quality issues in rare cancers

Publication date: January 2019Source: European Journal of Surgical Oncology, Volume 45, Issue 1Author(s): S. Sandrucci, P. Naredi, S. BonvalotAbstractThere are several suggestions that centralization of care improves outcome for rare cancers, particularly when optimal treatment requires complex surgery or high-technology radiotherapy equipment. Diagnosis and treatment in reference centers are expected to be more accurate because they benefit from large numbers of cases discussed in a multidisciplinary tumor board with a well-run pathway. However, centralization is sometimes moderately perceived by oncologists as a solution to be endorsed for rare cancer patients; disadvantages of centralization are the need for patients to move and the risk of a longer waiting list, with discomfort and possible negative effects on outcome. It is difficult to find single experts on rare cancers: all the more it will be difficult to find a multidisciplinary panel of experts, and the role of the surgeon is to be a functional part of it. On the other side, from a surgical point of view, the quality of the initial management of many rare cancers directly impacts the final outcome; surgery of rare cancers may not necessarily be more demanding than the average from a technical point of view, but the lack of cultural knowledge about the disease can well lead to inappropriateness even in the lack of major technical challenges. Care for rare cancer patients must be organized in pathways that cover the ...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research

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Source: Pediatric Hematology and Oncology - Category: Pediatrics Authors: Source Type: research
This study aimed to offer a reference for the rational indications of AT.Methods: We retrospectively included 1216 stage IB GC who experienced curative surgery from the SEER database between 2004 and 2015. These patients were allocated into two groups: Group AT and Group surgery alone (Group SA). We established a nomogram to predict OS and then divided whole cohort into low-risk and high-risk groups based on the OS predicted by the nomogram.Results: Six variables, which were significantly related with OS of entire patients after matched, were incorporated in the nomogram. These variables were age, examined lymph nodes, tum...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
In this study, we demonstrate the use of lipids as co-surfactants for the preparation of mixed micelles to improve the siRNA delivery of cholic acid-based block copolymers. Poly(allyl glycidyl ether) (PAGE) and poly(ethylene glycol) (PEG) were polymerized on the surface of cholic acid to afford a star-shaped block copolymer with four arms (CA-PAGE-b-PEG)4. The allyl groups of PAGE were functionalized to bear primary or tertiary amines and folic acid was grafted onto the PEG chain end to increase cell uptake. (CA-PAGE-b-PEG)4 functionalized with either primary or tertiary amines show high siRNA complexation with close to 10...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 24 January 2020Source: International Journal of PharmaceuticsAuthor(s): Kharkar Prachi Balaram, Talkar Swapnil Sunil, Patravale Vandana BharatAbstractThe aim of this study is to formulate thermodynamically stable docetaxel loaded nanostructured lipid carriers (DTX-NLCs) for parenteral cancer therapy with improved long term stability and better pharmacokinetic performance. DTX-NLCswere formulated using microemulsion(ME) template technique and characterized for particle size,entrapment efficiency (EE%), drug content and in vitro release kinetics. Further evaluation of NLCs was carried out b...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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Source: Journal of Psychosocial Oncology - Category: Cancer & Oncology Authors: Source Type: research
Publication date: Available online 25 January 2020Source: Artificial Intelligence in MedicineAuthor(s): Asha Das, Madhu S. Nair, David Peter S.AbstractBreast cancer is the most prevalent invasive type of cancer among women. The mortality rate of the disease can be reduced considerably through timely prognosis and felicitous treatment planning, by utilizing the computer aided detection and diagnosis techniques. With the advent of whole slide image (WSI) scanners for digitizing the histopathological tissue samples, there is a drastic increase in the availability of digital histopathological images. However, these samples are...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
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Source: Gut Microbes - Category: Microbiology Authors: Source Type: research
Publication date: Available online 24 January 2020Source: Research in MicrobiologyAuthor(s): Hong-Wei Pan, Lu-Tao Du, Wei Li, Yong-Mei Yang, Yi Zhang, Chuan-Xin WangAbstractThe host-associated gut microbiota is considered critical for the occurrence and progression of colorectal cancer (CRC); however, systematic evaluations of the changes in the biodiversity and richness of mucosa-associated gut microbiota with the development of CRC have been limited. Twenty-three paired samples from colorectal tumor sites and the surrounding non-tumor tissues were collected from stage I to IV CRC patients. The microbial compositions of t...
Source: Research in Microbiology - Category: Microbiology Source Type: research
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