Evidence-based data and rare cancers: The need for a new methodological approach in research and investigation

Publication date: January 2019Source: European Journal of Surgical Oncology, Volume 45, Issue 1Author(s): S. Mathoulin-Pélissier, K. Pritchard-JonesAbstractRare cancers are not so rare, their incidence is increasing and, as a group, they have worse survival than the common cancers. These factors emphasise the societal need to ensure sufficient focus on research into their biological basis, aetiological factors, new more effective therapies and organisation of healthcare to improve access to best practice and innovation. Accuracy of diagnosis is one of the first hurdles to be overcome, with around one third of tumours being reclassified – by type or risk group – when subject to a centralised pathology review process. Timely access to appropriate expert knowledge is a second challenge for patients – in Europe this is being addressed by the establishment of European Reference Networks (ERNs) as part of the EU cross border healthcare initiative. There are ERNs for adult solid and haematological cancers and childhood cancers, all of which are individually rare. These ERNs will facilitate creation of large databases of rare tumours that will incorporate knowledge of their molecular features and build an evidence base for the effectiveness of innovative, biology-directed therapies. With an increasing focus on ‘real world’ outcome data, research methodologies are evolving, to include randomised registry trials and data linkage approaches that expl...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research

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Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Syndicated Local Dr. Mallika Marshall Skin Cancer Source Type: news
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Source: Physiotherapy Canada - Category: Physiotherapy Authors: Tags: Physiother Can Source Type: research
Pharmaceutical company Teva USA announced today that it will resume production of childhood cancer drug vincristine after a recent shortage which led to patients missing doses of the vital chemotherapy.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
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Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Family Medicine, Internal Medicine, Allergy, Emergency Medicine, Oncology, Pathology, Pediatrics, Pulmonology, Conference News, Source Type: news
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Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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