Evidence-based data and rare cancers: The need for a new methodological approach in research and investigation
Publication date: January 2019Source: European Journal of Surgical Oncology, Volume 45, Issue 1Author(s): S. Mathoulin-Pélissier, K. Pritchard-JonesAbstractRare cancers are not so rare, their incidence is increasing and, as a group, they have worse survival than the common cancers. These factors emphasise the societal need to ensure sufficient focus on research into their biological basis, aetiological factors, new more effective therapies and organisation of healthcare to improve access to best practice and innovation. Accuracy of diagnosis is one of the first hurdles to be overcome, with around one third of tumours being reclassified – by type or risk group – when subject to a centralised pathology review process. Timely access to appropriate expert knowledge is a second challenge for patients – in Europe this is being addressed by the establishment of European Reference Networks (ERNs) as part of the EU cross border healthcare initiative. There are ERNs for adult solid and haematological cancers and childhood cancers, all of which are individually rare. These ERNs will facilitate creation of large databases of rare tumours that will incorporate knowledge of their molecular features and build an evidence base for the effectiveness of innovative, biology-directed therapies. With an increasing focus on ‘real world’ outcome data, research methodologies are evolving, to include randomised registry trials and data linkage approaches that expl...
ConclusionsThis is the first sun protection accreditation program developed for Spanish schools. Studies are needed to evaluate how this program is received and how it affects students’ sun protection behaviors.ResumenIntroducciónLa exposición solar en la infancia es el principal factor de riesgo para el desarrollo de cáncer de piel en la vida adulta. Las intervenciones basadas en programas y políticas de fotoprotección escolar han demostrado ser las estrategias más eficaces y coste-efectivas para la prevención del cáncer de piel.ObjetivosElaborar un modelo de c...
BOSTON (CBS) — Melanoma is the deadliest form of skin cancer, but a new study published in JAMA Dermatology finds melanoma rates are actually dropping, at least in young people. Melanoma is linked to exposing skin to ultraviolet light (UV), most notably through sunburns during childhood. Researchers looked at data from almost a million cases of invasive melanoma between 2006 and 2015, and found that while the rates ticked up in adults over 40, they dropped 23% among adolescents and adults under 30. They say this suggests that public health efforts to get people to use sun protection and avoid excessive UV exposure is working.
Conclusions: Collaborative efforts to conduct multi-centre trials are needed to further the field of paediatric oncology PT. PMID: 31719724 [PubMed]
Pharmaceutical company Teva USA announced today that it will resume production of childhood cancer drug vincristine after a recent shortage which led to patients missing doses of the vital chemotherapy.
More than 20 percent of those with family history of cancer had childhood asthma
(Children's Cancer Institute Australia) An Australian-led international research effort has broken fresh ground in the race to find more effective treatments for the childhood cancer neuroblastoma, by uncovering a new and as-yet unexploited target in cancer cells that therapeutic drugs can be aimed at.
E-cigarettes may be more harmful to a smoker’s heart than traditional tobacco cigarettes. That’s the finding of new research from Cedars-Sinai Medical Center in Los Angeles, presented today (Nov. 11) at an American Heart Association scientific conference. The Cedars-Sinai team compared the hearts of 10 non-smokers to the hearts of 10 tobacco smokers and 10 e-cigarette smokers. All the people in the study were younger than 40, and all were otherwise healthy. In response to a mild bout of exercise, measures of blood flow increased in the hearts of the non-smokers. Among the tobacco smokers, this increase was blun...
Conclusion: Survivors of hepatoblastoma are at risk for long-term complications. They require long-term monitoring for late effects.
ConclusionsThe LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.
(American College of Allergy, Asthma, and Immunology) New study being presented at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Houston shows an association between a family history of cancer and a childhood asthma diagnosis.