Clinical Features, Diagnosis, and Outcome of Encephalitis in French Guiana.

Clinical Features, Diagnosis, and Outcome of Encephalitis in French Guiana. Am J Trop Med Hyg. 2018 Dec 17;: Authors: Roux A, Houcke S, Sanna A, Mathien C, Mayence C, Gueneau R, Liegeon G, Walter G, Resiere D, Elenga N, Resin G, Djossou F, Hommel D, Kallel H Abstract The aim of our study was to describe the clinical features, the etiologies, and the factors associated with poor outcome of encephalitis in French Guiana. Our study was retrospective, including all cases of encephalitis hospitalized in the Cayenne General Hospital, from January 2007 to July 2017. Patients were included through the 2013 encephalitis consortium criteria and the outcome was evaluated using the Glasgow outcome scale at 3 months from the diagnosis of encephalitis. We included 108 patients, giving an approximate incidence rate of four cases/100,000 inhabitants/year. The origin of the encephalitis was diagnosed in 81 cases (75%), and 72 of them (66.7%) were from an infectious origin. The most common infectious causes were Cryptococcus sp. (18.5%) independently of the immune status, Toxoplasma gondii (13.9%), and Streptococcus pneumoniae (5.5%). In the follow-up, 48 patients (46.6%) had poor outcome. Independent risk factors associated with poor outcome at 3 months were "coming from inside area of the region" (P = 0.036, odds ratio [OR] = 4.19; IC 95% = 1.09-16.06), need for mechanical ventilation (P = 0.002, OR = 5.92; IC 95% = 1.95-17.95), and age ≥ 65 years...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research