t(3;8)(q26.2;q24) Often Leads to MECOM /MYC Rearrangement and is Commonly Associated with Therapy-Related Myeloid Neoplasms and/or Disease Progression

We report 20 patients with t(3;8)(q26.2,q24): eight had therapy-related acute myeloid leukemia (AML), three therapy-related myelodysplastic syndrome, four blast phase of chronic myeloid leukemia, one relapsed AML, one AML transformed from chronic myelomonocytic leukemia, one blast phase of an unclassifiable myeloproliferative neoplasm, one de novo myelodysplastic syndrome, and one de novo AML.

Source: Journal of Molecular Diagnostics - December 18, 2018 Category: Pathology Authors: Guilin Tang, Shimin Hu, Sa A. Wang, Wei Xie, Pei Lin, Jie Xu, Gokce Toruner, Ming Zhao, Jun Gu, Madison Doty, Shaoying Li, L. Jeffrey Medeiros, Zhenya Tang Tags: Regular Article Source Type: research