PERSPECTIVES Manipulation of the Mononuclear Phagocyte System by Mycobacterium tuberculosis

Over the past 20 years, there has been an emerging appreciation about the role of the mononuclear phagocyte system (MPS) to control and eradicate pathogens. Likewise, there have been significant advances in dissecting the mechanisms involved in the microbial subversion of MPS cells, mainly affecting their differentiation and effector functions. Mycobacterium tuberculosis is a chronic bacterial pathogen that represents an enigma to the field because of its remarkable ability to thrive in humans. One reason is that M. tuberculosis renders a defective MPS compartment, which is perhaps the most ingenious strategy for survival in the host given the prominence of these cells to modulate microenvironments, their function as sentinels and orchestrators of the immune response, and their pathogenic role as reservoirs for microbial persistence. In this article, the principal strategies used by M. tuberculosis to subvert the MPS compartment are presented along with emerging concepts.
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Tuberculosis PERSPECTIVES Source Type: research

Related Links:

Publication date: Available online 27 January 2020Source: Current Medicine Research and PracticeAuthor(s): K.K. Chopra, Shweta SinghAbstractTuberculosis (TB) has remained a disease of public health importance since ages, affecting more than 10 million people globally and taking lives of 2 million people worldwide every year. Despite the dramatic improvements made in providing high-quality TB diagnostic services, since the discovery of the causative bacilli, many people with TB remain undiagnosed or get diagnosed only after long delays. Ten countries account for 77% of this gap and use only smear microscopy for diagnosis, w...
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
Publication date: Available online 21 February 2020Source: Microbes and InfectionAuthor(s): Patrick Howlett, Elsa Du Bruyn, Hazel Morrison, Isiguzo C. Godsent, Katalin A. Wilkinson, Mpiko Ntsekhe, Robert J. WilkinsonAbstractTuberculous pericarditis is a severe form of extrapulmonary tuberculosis and is the commonest cause of pericardial effusion in high incidence settings. Mortality ranges between 8-34%, and it is the leading cause of pericardial constriction in Africa and Asia. Current understanding of the disease is based on models derived from studies performed in the 1940-50s. This review summarises recent advances in ...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Publication date: April 2020Source: Cancer Epidemiology, Volume 65Author(s): Faezeh Salamat, Mahmoud Khandashpour, Mohammad Naeimi-Tabiei, Ali Ariannia, Mohammad Ashaari, SeyedMehdi Sedaghat, Fatemeh Ghasemi-Kebria, Fatemeh Salamat, Abbas Moghaddami, Susan Hasanpour-Heidari, Reza Hoseinpour, Nastaran Jafari-Delouei, Hamid Ghayoriardahaei, Masoomeh Gholami, Abdolreza Fazel, Gholamreza Roshandel, Jacques Ferlay, Elisabete WeiderpassAbstractIntroductionWe aimed to present the time trends and geographical distribution of lung cancer in Golestan province, a high-risk area for pulmonary tuberculosis (TB) in Northern Iran (2004-2...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: 20 February 2020Source: Cell, Volume 180, Issue 4Author(s): Jonathan M. Stokes, Kevin Yang, Kyle Swanson, Wengong Jin, Andres Cubillos-Ruiz, Nina M. Donghia, Craig R. MacNair, Shawn French, Lindsey A. Carfrae, Zohar Bloom-Ackerman, Victoria M. Tran, Anush Chiappino-Pepe, Ahmed H. Badran, Ian W. Andrews, Emma J. Chory, George M. Church, Eric D. Brown, Tommi S. Jaakkola, Regina Barzilay, James J. CollinsSummaryDue to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting mole...
Source: Cell - Category: Cytology Source Type: research
ConclusionOur novel rabbit LAM-specific mAbs performed well at recognizing LAM from slow-growing pathogenic mycobacteria, supporting their future diagnostic potential.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Multidrug resistant tuberculosis (MDR-TB) remains a serious public health problem with poor treatment outcomes. Predictors of poor outcomes vary in different regions. Vietnam is among the top 30 high burden of...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Publication date: Available online 21 February 2020Source: MethodsXAuthor(s): Paul O'Brien, Christopher Vinnard, Selvakumar SubbianABSTRACTTuberculous meningitis (TBM), caused by Mycobacterium tuberculosis (Mtb), is the deadliest form of tuberculosis in humans, particularly in children and the geriatric population. However, the host-pathogen interactions underlying TBM is not well understood. Rabbits are a valuable model system to study TB in humans. The rabbit model of TB recapitulates several pathophysiological characteristics, including heterogeneity, architecture, and development of granulomas at the site of infection ...
Source: MethodsX - Category: Science Source Type: research
Conclusion: The findings, such as the inverse relationship with tuberculosis treatment discontinuation in the group of people with comorbidity, reinforce the importance of integrated actions in health services to change the scenario of this challenging comorbidity.
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
We report an elderly male who presented with cough and fever and had pulmonary infiltrates suspicious of tuberculosis. Bronchoalveolar lavage microbiology including XpertMTB/Rif assay was non-contributory. Contrast enhanced computed tomography scan of abdomen revealed multiple non-enhancing lesions in the spleen. Ultrasound guided splenic aspirate revealed pus that was positive for Mycobacterium tuberculosis in XpertMTB/Rif assay confirming the diagnosis of tuberculosis. PMID: 32072799 [PubMed - in process]
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
ConclusionsThis comparative study has shown that the use of MALDI-tof for identification of Mycobacteria has resulted in a reduction in turnaround times, a dramatic reduction in the cost of identification and less preparation time in the laboratory. Overall, the results show that MALDI-tof appears to be a suitable replacement for the Genotype CM assay in the routine clinical Mycobacteriology laboratory and the methods described herein can act as a roadmap for other laboratories to implement the technology successfully. PMID: 32072855 [PubMed - as supplied by publisher]
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research
More News: Research | Tuberculosis