PERSPECTIVES Curing Color Blindness--Mice and Nonhuman Primates

It has been possible to use viral-mediated gene therapy to transform dichromatic (red-green color-blind) primates to trichromatic. Even though the third cone type was added after the end of developmental critical periods, treated animals acquired red-green color vision. What happened in the treated animals may represent a recapitulation of the evolution of trichromacy, which seems to have evolved with the acquisition of a third cone type without the need for subsequent modification to the circuitry. Some transgenic mice in which a third cone type was added also acquired trichromacy. However, compared with treated primates, red-green color vision in mice is poor, indicating large differences between mice and monkeys in their ability to take advantage of the new input. These results have implications for understanding the limits and opportunities for using gene therapy to treat vision disorders caused by defects in cone function.
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Retinal Disorders: Genetic Approaches to Diagnosis and Treatment PERSPECTIVES Source Type: research

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Jake Ternent, 22, from Ludworth, Co Durham had resigned himself to going completely blind due to an inherited degenerative eye condition. However, pioneering gene therapy may reverse the damage.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Blindness and visual impairment Medical research Disability Health Society Science Conservatives Source Type: news
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Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
Spark will continue its operations in Philadelphia as an independent company within the Roche Group             Basel, 17 December 2019 - Roche (SIX: RO, ROG; OTCQX: RHHBY) and Spark Therapeutics, Inc. (NASDAQ: ONCE) ( “Spark”) today announced the completion of the acquisition following the receipt of regulatory approval from all government authorities required by the merger agreement. Commenting on this important step forward, Severin Schwan, CEO of Roche, said, “We are excited about this important milestone because we believe that together...
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
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Source: Roche Media News - Category: Pharmaceuticals Source Type: news
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Source: Roche Media News - Category: Pharmaceuticals Source Type: news
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Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Single treatment using advanced microsurgery can cure condition for life
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news
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