Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1 [Microbiology]

Seneca Valley virus (SVV) is an oncolytic picornavirus with selective tropism for neuroendocrine cancers. SVV mediates cell entry by attachment to the receptor anthrax toxin receptor 1 (ANTXR1). Here we determine atomic structures of mature SVV particles alone and in complex with ANTXR1 in both neutral and acidic conditions, as...

http://www.pnas.org/content/115/51/13087.short?rss=1

Source: Proceedings of the National Academy of Sciences - December 18, 2018 Category: Science Authors: Lin Cao, Ran Zhang, Tingting Liu, Zixian Sun, Mingxu Hu, Yuna Sun, Lingpeng Cheng, Yu Guo, Sheng Fu, Junjie Hu, Xiangmin Li, Chengqi Yu, Hanyang Wang, Huanchun Chen, Xueming Li, Elizabeth E. Fry, David I. Stuart, Ping Qian, Zhiyong Lou, Zihe Rao Tags: Biological Sciences Source Type: research