Clinical Trial Tests CAR T-Cell Therapy on Peritoneal Mesothelioma

The National Cancer Institute in Rockville, Maryland, has opened an innovative clinical trial for patients with peritoneal mesothelioma that will explore the safety and effectiveness of a novel CAR T-cell therapy. The phase I trial also is being conducted at Washington University in St. Louis. It is aimed at patients whose disease has relapsed after initial chemotherapy treatment. It involves a laboratory modification of a patient’s T cells — a type of white blood cell — that can help the immune system kill the cancer. CAR T-cell therapy is a form of gene therapy that has been highly successful with blood and bone marrow cancers. The U.S. Food and Drug Administration first approved the therapy in 2017 for pediatric leukemia. “If it works well here, it could change the way [peritoneal mesothelioma] is treated in a relapsed setting,” Dr. Christina Annunziata, clinical director and principal investigator at the National Cancer Institute, told The Mesothelioma Center at Asbestos.com. “I’m excited about this one.” Laboratory Reprograming of T Cells This is a dose-escalation study that uses MCY-M11 as part of the laboratory reprograming. MCY-M11 is a novel drug developed by MaxCyte, a global life-sciences and pharmaceutical company based in Gaithersburg, Maryland. This is the first time the formula has been used in patients with peritoneal mesothelioma, which begins in the lining around the abdomen. Modified T cells will be returned...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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In this study, molecular dynamics simulations and molecular mechanics generalized Born surface area (MM-GB/SA) calculations were performed to investigate the molecular mechanism of Asciminib resistance induced by the two mutants. The obtained results indicate that the mutations have adversely influence on the binding of Asciminib to BCR-ABL, as the nonpolar contributions decline in the two mutants. In addition, I502L mutation causes α-helix I’ (αI′) to shift away from the helical bundle composed of αE, αF, and αH, making the distance between αI’ and Asciminib increased....
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
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Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
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Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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Source: The Journal of Supercritical Fluids - Category: Chemistry Source Type: research
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Source: European Polymer Journal - Category: Chemistry Source Type: research
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Source: European Polymer Journal - Category: Chemistry Source Type: research
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Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
In this study, we reported a dual HDAC and DNMT inhibitor 208 and found it induced G1 cell cycle arrest and apoptosis in U937 cells. Proteome and bioinformatic analyses revealed that the combined inhibition of DNMT1 and HDAC by 208 affected the expression of a series of proteins involved in many biological processes. We observed that several proteins associated with G1 cell cycle arrest and apoptosis were down regulated after 208 treatment, including p85α, MEK, and CDK4, suggesting that 208 induces cell cycle arrest and apoptosis through the p85α/MEK-mediated pathway in U937 cells. Moreover, biological function...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Study involving reimplanting testicular tissue later in life hailed as breakthroughTesticular tissue taken from young monkeys, which is then frozen and grafted back into their bodies later in their life, can give rise to sperm and allow them to father live young, scientists have revealed.While the approach has previously been successful in other animals, including mice, it is the first time a primate has produced offspring from the procedure. The team report the baby rhesus macaque that was born is a healthy female that has been named Grady, after “graft-derived” and “baby”.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Science Fertility problems Health Society Cancer Young people Animals World news Source Type: news
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