Sofosbuvir rids organism of chikungunya and yellow fever viruses

(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) Sofosbuvir is already used to treat hepatitis C and has passed all human use approval tests, so it can be fairly easily deployed if the chikungunya epidemic forecast for the next two years materializes.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

Related Links:

This study aimed to evaluate the effects of LLV on HCC development, mortality, and cirrhotic complications among patients according to their adherence to entecavir (ETV) treatment. Methods: We performed a retrospective observational analysis of data from 894 consecutive adult patients with treatment-naïve CHB undergoing ETV treatment. LLV was defined according to either persistent or intermittent episodes of
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
Authors: Woo HY, Park JY, Bae SH, Kim CW, Jang JY, Tak WY, Kim DJ, Kim IH, Heo J, Ahn SH Abstract Background/Aims: Suboptimal responses to lamivudine or telbivudine plus adefovir (LAM/LdT+ADV) rescue therapy are common in patients with LAM-resistant hepatitis B virus (HBV) infections. We compared patients switched to entecavir plus tenofovir (ETV+TDF) to those maintained on LAM/LdT+ADV. Methods: This prospective randomized controlled trial examined 91 patients whose serum HBV DNA levels were greater than 60 IU/mL after at least 24 weeks of treatment with LAM/LdT+ADV for LAM-resistant HBV. Patients were randomiz...
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
Publication date: Available online 25 May 2020Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Ludy Vargas, Fernanda Bastos, André Guimarães, Sávio Amaral, Tarcisio Fausto, Maria Arriaga, Manoel Sarno, Carlos Brites
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
CONCLUSION: MiR-98-5p inhibits the secretion of HBV, proliferation, migration, and invasion of HBV-HCC cells by targeting NIK. PMID: 32469170 [PubMed - in process]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
Conclusion: The current prevention and control measures have effectively reduced the transmissibility of COVID-19; however, R 0t is still larger than the threshold 1. The results show that the government adopting the Wuhan lockdown strategy plays an important role in restricting the potential infected persons in Wuhan outflow from the epidemic area and avoiding a nationwide spread by quickly controlling the potential infection in Wuhan. Meanwhile, since Jan. 18, 2020, the people successively accessed COVID-19-related information via the Internet, which may help to effectively implement the government's prevention and contr...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusion: The T-cell epitope-based peptide vaccine was designed for COVID-19 using the envelope protein as an immunogenic target. Nevertheless, the proposed vaccine rapidly needs to be validated clinically in order to ensure its safety and immunogenic profile to help stop this epidemic before it leads to devastating global outbreaks. PMID: 32461973 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Authors: Stefano ML, Kream RM, Stefano GB Abstract The emergence of the novel ß-coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic of coronavirus disease 2019 (COVID-19). Clinical studies have documented that potentially severe neurological symptoms are associated with SARS-CoV-2 infection, thereby suggesting direct CNS penetration by the virus. Prior studies have demonstrated that the destructive neurological effects of rabies virus (RABV) infections are mediated by CNS transport of the virus tightly bound to the nicotinic acetylcholine receptor (nACh...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
The novel coronavirus (SARS-CoV-2) that arose in China in December 2019 resulted in an epidemic that quickly expanded with particular intensity in the United States and European countries, particularly Italy and Spain, devastating the foundations of our nations in one of the most significant public health threats of our time. Sadly, this disease has spread globally, and from March 12 on, the American Society for Reproductive Medicine and European Society of Human Reproduction and Embryology made similarly cautious recommendations on managing patients who were undergoing infertility therapy or desiring pregnancy, but withou...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Inklings Source Type: research
Authors: Buckenmaier CC PMID: 32463085 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
America ’s decades-long relationship with the organization has been instrumental in improving health around the world.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus (2019-nCoV) World Health Organization Presidential Election of 2020 United States Politics and Government Epidemics Centers for Disease Control and Prevention League of Nations Trump, Donald J Henderson, Donald A Frieden, Tho Source Type: news
More News: Chikungunya | Epidemics | Epidemiology | Hepatitis | Hepatitis C | Infectious Diseases | Yellow Fever