Novel, Lean and Environment-friendly Granulation Method: Green Fluidized Bed Granulation (GFBG)

Publication date: Available online 17 December 2018Source: International Journal of PharmaceuticsAuthor(s): Hiroshi Takasaki, Atsushi Sakurai, Takuma Katayama, Yuka Matsuura, Naoko Ohyagi, Koichi Wada, Agata Ishikawa, Etsuo YonemochiAbstractThe Green fluidized bed granulation (GFBG) technology is based on the moisture activated dry granulation (MADG) technique and consists only of a mixing and spraying process using a fluidized bed granulator, requiring no heating process. This provides a less energy-consuming and environment-friendly granulation method compared to current fluidized bed granulation (FBG) and high-shear granulation (HSG) methods. The aim of this study is to compare and evaluate the manufacturability, and granule and tablet properties among GFBG, MADG, FBG and HSG.The GFBG process time took less than 20 min for producing final blends at a 700 g scale, which was comparable to MADG. This process time was significantly shorter than that of FBG and HSG. GFBG not only had the shortest process time but also reduced the number of manufacturing machines compared to FBG and HSG.The Hausner ratio (HR) of granules from GFBG (1.30) indicated a good flowability, and no problems were observed in the tablet mass variability during compression.Tablets produced using GFBG achieved sufficient tensile strength (>1.5 MPa) even at a low compression force and demonstrated the fastest disintegration time compared to the other manufacturing methods. Tablet disintegratio...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research