AI could bring ultralow-dose imaging to amyloid PET

With the help of artificial intelligence (AI), researchers have developed a...Read more on AuntMinnie.comRelated Reading: Deep-learning algorithm predicts Alzheimer's disease Are amyloid PET scans ready for the clinical setting? PET links amyloid, vascular factors to cognitive decline Artificial intelligence guides lower PET tracer dose Is seeing believing in imaging artificial intelligence?
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Brain maps based on functional MRI (fMRI) scans are proving useful in predicting...Read more on AuntMinnie.comRelated Reading: Can MRI of healthy brains explain head trauma damage? Advanced MRI technique confirms dementia risk PET, MRI show physical activity aids brain health MRI links brain region to dementia, auditory deterioration DTI-MRI offers window into Alzheimer's risk
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Researchers at the University of Turku have discovered new changes in blood samples associated with Alzheimer’s disease. A new study was conducted on disease-discordant Finnish twin pairs: one sibling suffering from Alzheimer's disease and the other being cognitively healthy. The researchers used the latest genome-wide methods to examine the twins' blood samples for any disease-related differences in epigenetic marks which are sensitive to changes in environmental factors. These differences between the siblings were discovered in multiple different genomic regions. Development of the late-onset form of Al...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news
DiscussionOur results suggest a sexual dimorphism in BACE1-related upstream mechanisms of brain Aβ production and deposition. We argue that plasma BACE1 should be considered in further biomarker validation and qualification studies as well as in BACE1 clinical trials.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
MRI scans of patients with traumatic head injuries have revealed microbleeds...Read more on AuntMinnie.comRelated Reading: Deep-learning model detects cerebral microbleeds on MRI Key MRI markers link vascular brain injury to health risks MRI offers possible link between microbleeds, Alzheimer's Brain MRI offers new insight into blood deposits SIIM: AI can accurately detect cerebral microbleeds
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
A technology that originated at the University of Minnesota is well on its way to commercialization thanks to an investment award from Alzheimer's Drug Discovery Foundation (ADDF). The investment of up to $500,000 was awarded through the ADDF's Diagnostics Accelerator initiative. Toronto, Ontario-based RetiSpec licensed through the University of Minnesota's Technology Commercialization program. The technology (shown on the right) harnesses hyperspectral imaging and machine learning.  RetiSpec Eye Scanner 3.jpeg "We are focused on bringing to market a noninvasiv...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news
Conclusion[18F]RO948 and [18F]flortaucipir bound comparably in neocortical regions, but [18F]RO948 showed higher retention in the medial temporal lobe and lower intracerebral “off-target” binding. Time-dependent bias of SUVR estimates may prove less of a factor with [18F]RO948, compared with previous tau ligands.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
ConclusionWe suggest a one-step quantification method for amyloid PET via a deep learning model. The model is highly reliable to quantify the amyloid PET regardless of multicenter images and various radiotracers.
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Conditions:   Mild Traumatic Brain Injury;   Moderate Traumatic Brain Injury;   Mild Cognitive Impairment Interventions:   Device: No Intervention is used for this study but all subjects will be asked to complete EEG testing and an MRI scan.;   Procedure: No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure. Sponsor:   VA Boston Healthcare System Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
It seems that the tipping point has been reached in the Alzheimer's research and development community, in the sense that it is becoming more widely accepted that new approaches are needed. The failure to produce significant benefits to patients via clearance of amyloid from the brain by immunotherapy has spurred a great deal of theorizing, and several new and promising lines of work. For example, working on restoring age-related declines in drainage of cerebrospinal fluid might remove all metabolic waste from the brain. Alternatively, a focus on neuroinflammation and the role of dysfunctional microglia is suggested, parti...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
The objective of this study was to assess the usefulness of the appropriate use criteria (AUC) for amyloid imaging in an unselected cohort. METHODS: We calculated sensitivity and specificity of appropriate use (increased confidence and management change), as defined by Amyloid Imaging Taskforce in the AUC, and other clinical utility outcomes. Furthermore, we compared differences in post-positron emission tomography diagnosis and management change between "AUC-consistent" and "AUC-inconsistent" patients. RESULTS: Almost half (250/507) of patients were AUC-consistent. In both AUC-consistent and AU...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
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