NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system

Conclusions/SignificanceThese preliminary results suggest the potential utility of CSF metabolomics as a rapid screening test to enhance diagnostic accuracies and improve patient outcomes.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research

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AbstractElizabethkingia meningoseptica, a gram negative bacillus ubiquitous in the hospital environment, is known to infrequently cause serious neonatal infections, particularly meningitis which is associated with high mortality and neuromorbidity in survivors. The authors describe a healthy term newborn with no apparent risk factors who developedElizabethkingia meningoseptica sepsis and meningitis on day 6 of life. Diagnosis could be established only after a week of the illness by which time the baby developed refractory status epilepticus, ventriculitis and hydrocephalus. The isolate was susceptible to only ciprofloxacin...
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
Publication date: Available online 20 March 2019Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Jean-Yves Jenny, Michel Bonnin, Didier Mainard, French Society of Hip and Knee Surgery (SFHG), French Society of Orthopedic Surgery and Traumatology (CNP-SoFCOT)
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Intravenous immunoglobulin therapy is FDA approved for the immune-mediated peripheral nerve disorders Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy. Immunoglobulin therapy has been used increasingly with significant efficacy in the treatment of patients with disabling autoimmune forms of dysautonomia, which are most often small fiber (autonomic and/or sensory) polyneuropathies. It is recognized by most who treat these disorders, however, that patients with autonomic dysfunction treated with intravenous immunoglobulin therapy develop aseptic meningitis or severe ...
Source: European Neurology - Category: Neurology Source Type: research
A new analysis from Xcenda found that if Medicaid were to use one-size-fits-all value assessments like the Institute for Clinical and Economic Review ’s (ICER) framework as the basis for accessing a medicine, an estimated 42 to 99 percent of prescriptions to treat serious, complex conditions like cancer and multiple sclerosis may not be covered. This shows the dangerous effects using ICER’s value framework could have for some of the most vuln erable patients.
Source: The Catalyst - Category: Pharmaceuticals Authors: Tags: Access Medicaid The Value Collaborative Source Type: news
Publication date: March 2019Source: Biometric Technology Today, Volume 2019, Issue 3Author(s): Eurotunnel, which carries more than 11m road and rail passengers each year between the UK and France, is to introduce SAS PARAFE automatic facial recognition (AFR) technology at its travel terminals. The technology, designed and developed by IN Groupe, is being installed ahead of the ‘Brexit’ parting of the ways between the two countries.
Source: Biometric Technology Today - Category: Information Technology Source Type: research
With €1 billion valuation, the French healthcare software company is now a unicorn.
Source: mobihealthnews - Category: Information Technology Source Type: news
Publication date: Available online 19 March 2019Source: Pharmacological ResearchAuthor(s): Manish Kumar, Ritu Kulshrestha, Nirmal Singh, Amteshwar Singh JaggiAbstractImatinib is a tyrosine kinase inhibitor and is used as a first line drug in the treatment of Philadelphia-chromosome-positive chronic myeloid leukaemia and gastrointestinal stromal tumors. Being tyrosine kinase inhibitor, imatinib modulates the activities of Abelson gene (c-Abl), Abelson related gene (ARG), platelet-derived growth factor receptor (PDGFR), FMS-like tyrosine kinase 3 (FLT3), lymphocyte-specific protein (Lck), mitogen activated protein kinase (MA...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: These results provide insights into the sexual life of medical students. The rate of low sexual desire among women in medicine in our institution is higher than the world's standard. Additional research is needed. PMID: 30885445 [PubMed - as supplied by publisher]
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
Authors: Faivre S, Roche N, Lacerre F, Dealberto MJ Abstract OBJECTIVES: The main objective of the study was to assess 25-hydroxyvitamin D (25(OH)D) status in a psychiatric population in France according to psychiatric diagnoses. The secondary objective was to investigate a correlation between 25(OH)D and CRP. METHODS: A retrospective study from February 1st, 2014 to January 31, 2016, was carried out in a French psychiatric hospital. Inpatients with a 25(OH)D measure were included. Variables including ethnic origin, BMI, psychiatric diagnoses, medical history and CRP were collected. Factors associated with 25(O...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
[The interesting anti-H1 effects in maintenance insomnia: A reflection on the comparative advantages of doxylamine and doxepin]. Encephale. 2019 Mar 14;: Authors: Dupuis G, Vaugeois JM Abstract Doxylamine (Donormyl®, Lidene®, Generics) is commonly proposed by pharmacists as a sleeping pill which does not require a prescription. In France, today it is only prescribed for occasional insomnia in adults. In light of knowledge about the role of the histamine H1 inverse agonist drugs in the treatment of insomnia, and specifically the low dose doxepin (3 mg and 6 mg) marketed in the US ...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
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