Identification of novel miRNAs with potential role in Gastric Cancer diagnosis: In silico procedure

In this study, we retrieved miRNAs obtained by HTP method from OncoLnc database. Consequently, retrieved miRNAs were compared in literature-based databases such as PubMed. As a result, two lists including experimentally validated and predicted miRNAs were provided. We found 28 predicted miRNAs that so far had not been experimentally validated in GC. In the following, further bioinformatics analyses were performed to obtain the expression profile of both validated and predicted miRNAs in tumor and normal tissues. Also, the role of predicted miRNAs in other cancers, and their possible targets in apoptosis, metastasis and angiogenesis retrieved from related databases. By recognizing the miRNAs involved in initiation and progression of GC, they may be considered as potential biomarkers in GC early diagnosis or targeted treatment and lead to novel therapeutic strategies. We introduce 28 predicted miRNAs involved in GC pathogenesis by in silico analysis.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research