Oral bisphosphonates and incidence of cancers in patients with osteoporosis: a systematic review and meta-analysis

ConclusionsTaken together, oral BPs do not increase the risk of incidence of all-cause cancer; instead, they can reduce the incidence of breast, endometrial, and upper gastrointestinal cancers among the postmenopausal OP females. Our analysis stratified by gender suggests that oral BPs may increase the incidence of liver cancer in mixed genders, while no significant association was observed in females. Careful analysis of post-marketing data should be conducted to address the clinical relevance of our results on the putative association of oral BP use and liver cancer suggested by our meta-analysis.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research