A squamous cell carcinoma in a young woman with Lynch syndrome
AbstractLynch syndrome (LS) is an autosomal-dominant inherited disorder characterized by a predisposition to colorectal cancer and extracolonic cancers (particularly endometrium, ovary, stomach, small bowel, hepatobiliary tract, pancreas, urothelial tract, brain, and skin). Muir –Torre syndrome (MTS) is considered a phenotypical variant of LS, where patients develop sebaceous neoplasms and keratoacanthomas. Currently, only few studies and case reports suggest an association between LS and other skin cancers, such as Bowens’ disease, melanoma and squamous cell carcinoma (SCC). In this case-report we describe the case of a 33-year-old woman with LS and a provenMSH2 germline mutation, presenting with a SCC on the right cheek. Immunohistochemistry lacked MSH2 and MSH6 protein staining. The tumor showed a discordance between immunohistochemistry and micro-satellite instability status, for which a clear explanation cannot be provided yet. To conclude whether this pattern is indicative for SCC occurring in LS patients, further analyses of other LS patients presenting with SCC should be carried out. Our patient ’s young age and skin type (Fitzpatrick phototype VI) suggest a possible link between LS and cutaneous SCC.
This case series demonstrates that cytoreductive surgery for diffused peritoneal metastases from lung cancer can yield improved prognosis and long-term survival.Journal of Medical Case Reports
SAN FRANCISCO - A groundskeeper whose $289 million award against Monsanto Co. was ultimately reduced to $78 million in his glyphosate cancer lawsuit filed a brief on Sept. 30 in a California appeals court contending that the court should disregard the attempts of various amici curiae to "inappropriately inject" new arguments and issues into the appeal (DeWayne Johnson v. Monsanto Company, Nos. A155940 and A156706, Calif. App., 1st Dist.).
SAN FRANCISCO - Monsanto Co. on Sept. 30 filed a brief in California appellate court contending that the U.S. Environmental Protection Agency has determined that glyphosate, the active ingredient in the herbicide Roundup, is not likely to cause cancer and, therefore, Roundup would be "misbranded" if it included a cancer warning (DeWayne Johnson v. Monsanto Company, Nos. A155940 and A156706, Calif. App, 1st Dist.).
SAN FRANCISCO - The circuit mediator for the Ninth Circuit U.S. Court of Appeals on Oct. 4 released from the mediation program two glyphosate cases against Monsanto Co. in which a cancer victim is appealing a district court judge's reduction of his original damages award against the company. Monsanto is cross-appealing the district court's denial of its motion for judgment notwithstanding the verdict (JNOV) (Edwin Hardeman v. Monsanto Company, No. 19-16636, 9th Cir.).
ST. LOUIS - A state court judge in Missouri on Oct. 4 postponed indefinitely a cancer victim's lawsuit against Monsanto Co. related to the herbicide Roundup, which contains the active ingredient glyphosate (Walter Winston v. Monsanto Company, No. 1822-CC00515, Mo. Cir., St. Louis City).
WEST PALM BEACH, Fla. - Lowe's Home Centers LLC in an Oct. 4 answer tells a Florida federal court that it has not violated any laws by selling the herbicide Roundup, which contains the ingredient glyphosate, and it denies that glyphosate-containing products cause cancer (Yvette Helen Biddle v. Lowe's Home Centers LLC, No. 19-81251, S.D. Fla.).
New guidelines say exercise may help cancer patients live longer, or help you avoid getting cancer in the first place.
Conclusion: MDCT provides good results in detecting sinus fat, venous invasion and kidney-confined tumors, but evaluation of perinephric fat remains a difficult task, leading to reduced accuracy in T3a staging. PMID: 31607203 [PubMed - as supplied by publisher]
ConclusionThe tumour is notorious to cause local recurrence and metastases; hence, an early and accurate diagnosis, surgical and adjunctive chemoradiation and regular periodic follow-ups are of utmost importance for the successful management of sebaceous gland carcinoma of eyelids.
Conclusion Marjolin ulcer is a high-risk skin tumor. Patients with positive lymph node or with moderately differentiated squamous cell carcinoma have high chances of recurrence. Frequent and intense follow-up is required for at least 2 years.