Terrestrial Bird Migration and West Nile Virus Circulation Terrestrial Bird Migration and West Nile Virus Circulation

How have the flight paths of terrestrial birds impacted the circulation of West Nile virus?Emerging Infectious Diseases
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

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Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Short Communication Source Type: research
In this study, we demonstrate that 2'-C-methyl- or 4'-azido-modified nucleosides are highly effective inhibitors of WNV replication, showing nanomolar or low micromolar anti-WNV activity and negligible cytotoxicity in cell culture. One representative of C2'-methylated nucleosides, 7-deaza-2'-C-methyladenosine, significantly protected WNV-infected mice from disease progression and mortality. Twice daily treatment at 25 mg/kg starting at the time of infection resulted in 100% survival of the mice. This compound was highly effective, even if the treatment was initiated 3 days post-infection, at the time of a peak of viremia, ...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
S. E. Ronca et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
enzie Norovirus is an acute infection of the gastrointestinal tract causing rapid induction of vomiting and diarrhoea. The infection is sensed and controlled by the innate immune system, particularly by the RNA helicase MDA-5 and type I and III interferons (IFNs). We have observed that intracellular replication of murine norovirus (MNV) occurs in membranous clusters proximal to the microtubule organising centre, a localisation dependent on intact microtubules. Recently, it was shown that the host protein guanine nucleotide exchange factor-H1 (GEF-H1) is a microtubule-associated innate immune sensor that activates inter...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
V. Parkash et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
Flaviviruses are important pathogens for humans and animals (Dengue viruses, Yellow fever virus, Zika virus and West Nile virus). Culex flavivirus (CxFV) is an insect-specific virus of the genus Flavivirus, detec...
Source: Virology Journal - Category: Virology Authors: Tags: Short report Source Type: research
Abstract As at 12 November 2018, an outbreak of West Nile virus (WNV) was responsible for 139 WNV infection cases in Israel. Here, we characterise the epidemiology of the outbreak and demonstrate that only WNV lineage I was circulating in mosquitoes and responsible for WNV infection in humans. This suggests that the concurrence of the outbreak in Israel with WNV outbreaks in several European countries is not due to a common, more virulent WNV genotype. PMID: 30621816 [PubMed - in process]
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research
Abstract West Nile virus infection is more frequently associated with neuroinvasive disease and high morbidity and mortality in immunocompromised hosts. Here, we describe a 47-year-old Egyptian kidney transplant recipient who was admitted to our department in 2016 for persistent fever, altered mental status, and upper limb tremors. In addition, renal impairment, signs of acute thrombotic microangiopathy, pancreatitis, and slightly altered inflammatory indices were present. The patient was treated with antibacterial and antiviral therapy, and reduced immunosuppressive therapy was prescribed. After several biochemic...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
We read with great interest the study by Saltzman et. al. on nerve transfers for acute flaccid myelitis (AFM) [1]. AFM refers to acute flaccid paralysis with focal/ asymmetric limb weakness and characteristic spinal gray matter lesions on imaging. Besides poliomyelitis, an array of viruses may be causative. These include Non-Polio Enteroviruses (NPEV- Enterovirus D-68&A-71, Coxsackie A and B), Arboviruses (West Nile virus, Japanese B encephalitis virus (JEV)), Herpes viruses (Herpes simplex 1 and 2, varicella zoster virus, Ebstein Barr virus) etc.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Correspondence Source Type: research
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