Prevalence of Amyotrophic Lateral Sclerosis -- US, 2015 Prevalence of Amyotrophic Lateral Sclerosis -- US, 2015

The prevalence data presented in this report aims to further our understanding of the epidemiology of ALS cases in the United States.Morbidity &Mortality Weekly Report
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

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The aim of our study was to evaluate the role of mutations in theMAPT gene in patients with pure amyotrophic lateral sclerosis (ALS). A cohort of 120 ALS patients, both sporadic and familial, without cognitive impairment was analyzed by next-generation sequencing with a multiple-gene panel comprising 23 genes, includingMAPT, known to be associated with ALS and frontotemporal dementia. The presence of theC9orf72 expansion was also investigated. Twelve patients had mutations in theSOD1, TARDBP, MATR3, andFUS genes, while 10 patients carried theC9orf72 expansion. One female patient was found to carry the D348G mutation inMAPT...
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
Bridging biophysics and neurology: aberrant phase transitions in neurodegenerative disease, Published online: 19 March 2019; doi:10.1038/s41582-019-0157-5In this Review, Nedelsky and Taylor review the evidence that disturbances in phase transition dynamics and the material properties of ribonucleoprotein granules underlie the pathogenesis of many neurodegenerative diseases, including forms of amyotrophic lateral sclerosis and frontotemporal dementia, among others.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
We present evidence from previous works on the important phenotypic changes of various neuronal types in these neurological diseases. We also summarize efforts on conducting low- and high-throughput screening experiments with hiPSCs toward developing potential therapeutics for treatment of neurodegenerative diseases. Lastly, we discuss the limitations of hiPSCs culture system in studying neurodegenerative diseases and alternative strategies to overcome these drawbacks.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
Siobhan E. Kirk, Timothy J. Tracey, Frederik J. Steyn, Shyuan T. Ngo
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
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