Initial presentation determines clinical entity in patients with anti ‐centromere antibody positivity

ConclusionOur study confirmed that many ACA ‐positive cases can be classified into an autoimmune disease type on presentation.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Publication date: Available online 9 October 2019Source: NeuroImageAuthor(s): Aline M. Thomas, Jiadi Xu, Peter A. Calabresi, Peter C.M. van Zijl, Jeff W.M. BulteAbstractMultiple sclerosis (MS) is an autoimmune disorder that targets myelin proteins and results in extensive damage in the central nervous system in the form of focal lesions as well as diffuse molecular changes. Lesions are currently detected using T1-weighted, T2-weighted, and gadolinium-enhanced magnetic resonance imaging (MRI); however, monitoring such lesions has been shown to be a poor predictor of disease progression. Chemical exchange saturation transfer...
Source: NeuroImage - Category: Neuroscience Source Type: research
In this study, we detected for just the second time a SINV infection in a diseased wild bird (common wood pigeon) from Central Europe. SINV was isolated by cell culture and the complete SINV genome sequence was determined. Phylogenetic analyses revealed a close affiliation to SINV genotype I with a high similarity to human isolate sequences from Finland, Sweden and Russia. The isolate was genetically distinct from the first avian isolate suggesting the circulation of at least two different SINV strains in Germany.In order to reveal the infection frequency in SINV positive mosquito regions 749 bird blood samples were assaye...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
ConclusionStudies on arthroplasty survival should systematically mention gender and diabetes status and beware of potential group incomparability.Level of evidenceIII, cohort study.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Any of you have any luck successfully managing a patient who argues with you that their lab results are abnormal, demanding tests that aren't indicated? I have done more of a work up than most would have done at this point and I do not think more testing is warranted. Example platelets of 180 they state is "lower end of normal, and is therefore abnormal," "a basophil percentage of 0.3% is low" and wanting rheumatoid arthritis work up with only symptom being dyspepsia. Explaining that... Dealing with difficult patients
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Family Medicine Source Type: forums
Acid sphingomyelinase activity is elevated in serum of rheumatoid arthritis patients, suppressed by anti-TNF-α treatment. Clin Exp Rheumatol. 2019 Oct 08; Authors: Chung HY, Wickel J, Stuhlmüller B, Kinne RW, Claus RA PMID: 31603070 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Qiqi Xin, Rong Yuan, Weili Shi, Zhengchuan Zhu, Yan Wang, Weihong CongAbstractInflammatory disorders result from abnormal immune response and their incidence has increased recently. Thus, there is an urgent need to discover new treatments for inflammatory disorders. In recent years, the natural products contained in Chinese herbs have attracted much attention worldwide owing to their anti-inflammatory effects. Paeoniflorin (PF) is a bioactive compound purified from the Chinese herb Paeonia lactiflora and reports have recently emerged suggesti...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Roza Motavalli, Jalal Etemadi, Houman Kahroba, Amir Mehdizadeh, Mehdi YousefiAbstractIdiopathic membranous nephropathy (IMN) has recently attracted much attention due to the development of auto antibodies, anti-phospholipase A2 receptor and anti-thrombospondin type I domain-containing 7A on podocytes, the establishment of immune networks complexes in circulation as well as the development of autoreactive immune cells against kidney, in both innate and adaptive participants. The auto inflammatory responses in IMN leads to the dysfunction of gl...
Source: Life Sciences - Category: Biology Source Type: research
Authors: Toraih EA, Ameen HM, Hussein MH, Youssef Elabd AA, Mohamed AM, Abdel-Gawad AR, Fawzy MS Abstract Alopecia areata (AA) is a non-scarring hair loss of autoimmune etiology. The autoimmune regulator (AIRE) gene is believed to be an important driver in AA pathogenesis. Genetic variants can alter mRNA expression levels which may provoke an autoimmune response. A total of 337 males (97 AA patients and 240 controls) were enrolled in the current case-control study. On screening of the most frequent variants in the gene, rs2075876 (A/G) polymorphism in intron 5 was selected and genotyped using Real-Time PCR (polymer...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
AbstractIn recent years, mold has been blamed for many symptoms or a constellation of symptoms. These symptoms are usually vague and subjective and difficult or impossible to measure or quantify. Moreover, there is no scientific evidence that mold has anything to do with these symptoms. In particular, the concept of toxic mold syndrome has permeated the public consciousness, and mycotoxins have falsely been associated with autoimmune diseases and a variety of other conditions. In fact, there is no evidence that the presence of mycotoxins in the air is enough to cause any disease known to man. Molds legitimately can cause a...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Abstract Systemic sclerosis is a complex autoimmune connective tissue disease which carries a significant burden of disease-related morbidity including potentially life-threatening complications. Systemic sclerosis can affect all the major organs and therefore, although the disease is uncommon, many hospital-based specialists are involved in patient care. Vascular disease (e.g. Raynaud's phenomenon) is an almost universal symptom in patients with systemic sclerosis and is often the earliest manifestation of the disease. Systemic sclerosis not uncommonly can overlap with other rheumatological conditions (e.g. rheum...
Source: British Journal of Hospital Medicine - Category: Internal Medicine Authors: Tags: Br J Hosp Med (Lond) Source Type: research
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