Overactive immune system 'may trigger ME-like symptoms'

Researchers say the study is a "light in the fog" in the search for the causes of chronic fatigue syndrome.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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In conclusion, work demands generally worsen, while recovery experiences protect mental health during the COVID-19 pandemic with the caveat of the role of detachment experiences.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
ConclusionOur findings indicate that sBDNF levels are elevated in patients with CFS/FM and that BDNF methylation in exon 9 accounts for the regulation of protein expression. Altered BDNF levels might represent a key mechanism explaining CFS/FM pathophysiology.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
Publication date: November 2020Source: Multiple Sclerosis and Related Disorders, Volume 46Author(s): Heidi Ormstad, Cecilia Smith Simonsen, Line Broch, Dr Michael Maes, George Anderson, Elisabeth G. Celius
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
No abstract available
Source: Nursing Management - Category: Nursing Tags: Feature: CE Connection: Staff Development Source Type: research
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractAutoimmune syndrome induced by adjuvants (ASIA) is the spectrum of diseases in which the substances considered inert to the body induce autoimmune reactions and inflammation. Some of the biomaterials recently used in plastic surgery, such as silicone or polyacrylamide hydrogel (PAAG) seem to trigger clinical features of ASIA. The aim of this study was to assess the incidence of these features within a group of women after breast augmentation with PAAG. As many as 30 consecutive patients (26 –59 years, mean age 39.5) referred to the Clinic of Plastic Surgery after breast enhancement with PAAG were examine...
Source: Rheumatology International - Category: Rheumatology Source Type: research
AbstractChronic fatigue syndrome/myalgic encephalomyelitis (CFS) is a complex, multisystem disease that is characterized by long-term fatigue, exhaustion, disabilities, pain, neurocognitive impairments, gastrointestinal symptoms, and post-exertional malaise, as well as lowered occupational, educational, and social functions. The clinical and biomarker diagnosis of this disorder is hampered by the lack of validated diagnostic criteria and laboratory tests with adequate figures of merit, although there are now many disease biomarkers indicating the pathophysiology of CFS. Here, we review multiple factors, such as immunologic...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a serious and complex physical illness that affects all body systems with a multiplicity of symptoms, but key hallmarks of the disease are pervasi...
Source: Journal of Translational Medicine - Category: Research Authors: Tags: Research Source Type: research
Publication date: Available online 22 September 2020Source: Integrative Medicine ResearchAuthor(s): Seungwon Shin, Soo Jung Park, Minwoo Hwang
Source: Integrative Medicine Research - Category: Complementary Medicine Source Type: research
AbstractPhysiosomatic symptoms are an important part of schizophrenia phenomenology. The aim of this study is to examine the biomarker, neurocognitive and symptomatic correlates of physiosomatic symptoms in schizophrenia. We recruited 115 schizophrenia patients and 43 healthy controls and measured the Fibromyalgia and Chronic Fatigue Syndrome Rating (FF) scale, schizophrenia symptom dimensions, and the Brief Assessment of Cognition in Schizophrenia. We measured neuro-immune markers including plasma CCL11 (eotaxin), interleukin-(IL)-6, IL-10, Dickkopf protein 1 (DKK1), high mobility group box  1 protein (HMGB1) and end...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
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