Deadly Respiratory Distress Mimic
Conclusion It’s important for prehospital providers to be able to differentiate metabolic disturbances in the setting of respiratory distress and not be fooled into thinking tachypnea always has a respiratory cause. The physical exam and adjuncts such as end-tidal capnography can assist in the prehospital diagnosis. A COPD exacerbation generally presents as diminished lung sounds, wheezing on exhalation, and a prolonged expiratory phase. Here, a patient will attempt to compensate for the inflammation and mucus accumulation associated with the destruction and narrowing of peripheral airways and a subsequent lack of available space for air exchange. The EtCO2 may be increased in these patients as carbon dioxide accumulates due to air trapping; however, the physiologic deadspace associated with some forms or COPD may lower the EtCO2. Without knowing the patient’s baseline EtCO2, this value may be difficult to interpret in this setting and the physical exam will be more diagnostic. In this case, although the patient had a history of COPD and appeared to be in respiratory distress, her normal lung sounds and air entry heard on auscultation, the history of recent infection, and the decreased capnography reading suggested she likely had a metabolic acidosis associated with sepsis. References 1. Kellum JA. Metabolic acidosis in patients with sepsis: Epiphenomenon or part of the pathophysiology? Crit Care Resusc. 2004;6(3):197–203. 2. Fuller BM, Dellinger RP. L...
Authors: Ridruejo E, Garcia-Agudo R, Mendizabal M, Aoufi-Rabih S, Dixit V, Silva M, Fabrizi F Abstract BACKGROUND AND AIMS: The advent of direct-acting antiviral agents promises to change the management of hepatitis C virus infection (HCV) in patients with chronic kidney disease (CKD), a patient group in which the treatment of hepatitis C was historically challenging. We investigated the safety and efficacy of all-oral, interferon-free direct-acting antiviral agents for the treatment of hepatitis C in a 'real-world' cohort of patients with CKD. METHODS: We performed an observational single-arm multi-centre stud...
Contributors : Ruo-Pan Huang ; Xinchun ChenSeries Type : Protein profiling by protein arrayOrganism : Homo sapiensMycobacterium tuberculosis (Mtb) antigen-specific cellular response is promising for detectionof Mtb infection, but not efficient for diagnosis of TB. We firstly identified 16 TB disease-specific protein markers measured in the culture supernatant of Mtb-stimulated whole blood using a 640 human proteins array, the highest throughput antibody-based protein array available at the time when we did this study. Potential TB-related proteins were then analyzed across three different patient cohorts comprised of...
(Oxford University Press USA) A new study soon to appear in the Faculty of Public Health's Journal of Public Health, published by Oxford University Press, suggests that air pollution and living in apartment buildings may be associated with an increased risk for dangerous conditions like heart disease, stroke, and type 2 diabetes. This paper is embargoed until midnight EST on June 25.
Contributors : Caiyan Zhang ; Yufeng ZhouSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensTo determine ceRNA transcribed during the PBMCs, we have employed whole genome microarray expression profiling as a discovery platform to identify ceRNA expression in PBMCs donated by T1DM (type 1 diabetes mellitus) patients and healthy volunteers.
Contributors : Caiyan Zhang ; Yufeng ZhouSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensTo determine miRNA transcribed during the PBMCs, we have employed whole genome microarray expression profiling as a discovery platform to identify miRNA expression in PBMCs donated by T1DM (type 1 diabetes mellitus) patients and healthy volunteers.
Methicillin-resistantStaphylococcus aureus (MRSA) has become a serious problem, forcing doctors to turn to antibiotics other than penicillin or penicillin derivatives, or to different drug cocktails, which are often less effective in treating hospital and community based infections.
This study aimed to use in-depth, semi-structured interviews with seven young stroke survivors aged eighteen to sixty-five years to elucidate the specific challenges and priorities of members of this population.
The purpose of this study was to develop and test an initial algorithm for recognizing and classifying daily activities in an unstructured home environment using a depth sensor (VicoVR).
Authors: Blautain B, Souied EH, Cohen SY PMID: 31229323 [PubMed - as supplied by publisher]
Publication date: Available online 23 June 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Muneeb A. Faiq, Gadi Wollstein, Joel S. Schuman, Kevin C. ChanAbstractThe cholinergic system has a crucial role to play in visual function. Although cholinergic drugs have been a focus of attention as glaucoma medications for reducing eye pressure, little is known about the potential modality for neuronal survival and/or enhancement in visual impairments. Citicoline, a naturally occurring compound and FDA approved dietary supplement, is a nootropic agent that is recently demonstrated to be effective in ameliorating ischemi...
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