Serum rantes, transforming growth factor- β1 and interleukin-6 levels correlate with cardiac muscle fibrosis in patients with aortic valve stenosis.

Serum rantes, transforming growth factor-β1 and interleukin-6 levels correlate with cardiac muscle fibrosis in patients with aortic valve stenosis. J Physiol Pharmacol. 2018 Aug;69(4): Authors: Podolec J, Baran J, Siedlinski M, Urbanczyk M, Krupinski M, Bartus K, Niewiara L, Podolec M, Guzik T, Tomkiewicz-Pajak L, Komar M, Kablak-Ziembicka A Abstract Regulated on Activation Normal T Expressed and Secreted (RANTES) chemokine is involved in the initiation of inflammation and immune-cell recruitment. Interleukin -6 (IL-6) is used as a general index of severity of the chronic inflammatory process. Finally, transforming growth factor-β (TGF-β) is an immune biomarker potentially involved in the regulation of valve fibrosis and calcification. The aim of this study was to analyze selected biomarkers associated with the different stages of immune-pathogenesis in aortic stenosis. Forty consecutive patients with moderate to severe aortic stenosis (AS) and without previous myocardial infarction history were included in the study and divided into two groups. Two imaging techniques, echocardiography and magnetic resonance, were used to estimate the degree of AS and left ventricular muscle function. Inflammatory biomarker serum levels including CCL5/RANTES, IL-6, and TGF-β1 were determined based on ELISA measurements. Mean levels of RANTES, IL-6, and TGF-β1 did not significantly differ between both groups. A negative correlation was found betw...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research