Hypertension linked to allostatic load: from psychosocial stress to inflammation and mitochondrial dysfunction.

Hypertension linked to allostatic load: from psychosocial stress to inflammation and mitochondrial dysfunction. Stress. 2018 Dec 14;:1-13 Authors: Mocayar Marón FJ, Ferder L, Saraví FD, Manucha W Abstract Although a large number of available treatments and strategies, the prevalence of cardiovascular diseases continues to grow worldwide. Emerging evidence supports the notion of counteracting stress as a critical component of a comprehensive therapeutic strategy for cardiovascular disease. Indeed, an unhealthy lifestyle is a burden to biological variables such as plasma glucose, lipid profile, and blood pressure control. Recent findings identify allostatic load as a new paradigm for an integrated understanding of the importance of psychosocial stress and its impact on the development and maintenance of cardiovascular disease. Allostasis complement homeostasis and integrates behavioral and physiological mechanisms by which genes, early experiences, environment, lifestyle, diet, sleep, and physical exercise can modulate and adapt biological responses at the cellular level. For example, variability is a physiological characteristic of blood pressure necessary for survival and the allostatic load in hypertension can contribute to its related cardiovascular morbidity and mortality. Therefore, the current review will focus on the mechanisms that link hypertension to allostatic load, which includes psychosocial stress, inflammation, and mi...
Source: Stress - Category: Research Tags: Stress Source Type: research