Ql-07 * treatment of fatigue in a patient with corpus-callosum glioma and atypical sleep disorder

We present the case of a 53 year-old married gentleman with above-average IQ who has a high-grade glioma of the corpus callosum, severe fatigue, cognitive concerns, and an atypical sleep disorder. He has had severe daytime somnolence and poor concentration since childhood, with normal nighttime sleep. Since his teens, he has had two hours of alertness in the morning, followed by disabling sleepiness for the rest of the day. Epworth sleepiness scores have been extremely high (20 to 24). Diagnoses of ADHD, narcolepsy, and idiopathic hypersomnia had been applied, but he has not met full diagnostic criteria. From 2007 to 2012, escalating doses of stimulant medication were utilized, with the best response ("can attempt some household tasks" and "approaching a normal life" per his wife) on 400 mg modafinil, and 456 mg methylphenidate (seven times the recommended maximum). This allowed him to stay awake for some normal activities such as attending his child's baseball game. In June of 2012, the modafanil and methylphenidate were discontinued by his doctor because the sleep disorder could not be confirmed with polysomnograph and multiple sleep latency testing. The somnolence returned, and the patient became distraught and expressed suicidal ideation. He saw a psychotherapist who referred him to Neurology where the corpus callosum glioma was identified incidentally (biopsy confirmed grade III astrocytoma). Pre-treatment neuropsychological evaluation revealed impair...
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: QUALITY OF LIFE Source Type: research

Related Links:

CONCLUSION: CRP SNPs rs1800947 and rs2794521 may be associated with depressive symptoms in patients with depression in a sexspecific fashion. Furthermore, rs2794521 may be a predictor of the efficacy of antidepressants in female patients. PMID: 31711279 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
CONCLUSION: In conclusion, depression is associated with deficiency of TRP, Se, Vit D, Mg, and serotonin displays the characteristics of biomarkers. The correlation between TRP and other biomarkers/trace elements is also important in depression. PMID: 31711278 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
CONCLUSIONS: This paper presents five cases and a radiographic inventory to illustrate disturbances of dental development associated with chemotherapy and radiotherapy therapy in children. Medical and dental professionals involved in the treatment of cancer survivors are relatively unaware of the dental consequences of radiation therapy and the age dependency of specific regional effects. These effects can be severe, with great impact on quality of life. Further research in this area could help improve planning of radiation therapy for children, potentially preventing or limiting dental or maxillofacial sequelae. PMID:...
Source: Dentomaxillofacial Radiology - Category: Radiology Tags: Dentomaxillofac Radiol Source Type: research
In this study it is analyzed, whether shame-proneness and self-compassion moderate the influence of bully-experience on depressive symptoms. Data of depressive adolescent in-patients (n = 37) and healthy controls (n = 19) is analyzed. It could be shown that high shame-proneness reinforces the influence of bully-experience on depressive symptoms. General self-compassion has no moderating influence. However, self-kindness is a protective factor against the negative impact of bully-experience on depressive symptoms. Results are discussed regarding their relevance for therapy and prevention. PMID: 31711401 [PubMed - in process]
Source: Praxis der Kinderpsychologie und Kinderpsychiatrie - Category: Child Development Tags: Prax Kinderpsychol Kinderpsychiatr Source Type: research
Authors: Haid-Stecher N, Sevecke K Abstract Childhood Maltreatment and Non-Suicidal Self-Injury - the Impact of Emotion Regulation Non-suicidal self-injury (NSSI) is a common phenomenon in adolescence. Furthermore, it is often associated with maltreatment during childhood. One factor determining the relation between childhood maltreatment and NSSI is maladaptive emotion regulation strategies. The current study examines this relation in adolescent psychiatric inpatients (n = 97). Adolescents engaging in NSSI present maladaptive strategies in emotion regulation more frequently. In addition, they experienced maltreatm...
Source: Praxis der Kinderpsychologie und Kinderpsychiatrie - Category: Child Development Tags: Prax Kinderpsychol Kinderpsychiatr Source Type: research
AbstractKorean-American mental health is poorly understood, and screening for sleep disturbances may be an effective means of identifying at-risk individuals. In partnership with a Korean-American church in Los Angeles, an online survey was administered. The study was conducted at a Korean-American church in Los Angeles, California. The sample consisted of 137 Korean-Americans drawn from the church congregation. Sleep disturbances were measured using a single ordinal variable, and mental health outcomes included nonspecific psychological distress, perceived stress, loneliness, suicidal ideation, hazardous drinking, treatme...
Source: Journal of Immigrant and Minority Health - Category: International Medicine & Public Health Source Type: research
This study aimed to examine depressive symptoms in ruralurban migrant workers in mainland China, with a focus on the moderating roles of community factors (i.e., community support network, community cohesion and community composition) in the relation between work stress and depressive symptoms. This study used secondary data from a national representative study conducted by the Social Survey Center at SUN-YETSEN University of China in 2014. The final sample contained 1434 participants from 29 provinces of China (Mean age  = 36.47, SD = 11.91). Being female, lower self-rated health, lower levels ...
Source: Journal of Immigrant and Minority Health - Category: International Medicine & Public Health Source Type: research
OBJECTIVES: The aims of this study were to assess evidence for a novel, universal mental health literacy programme in the school setting (teen Mental Health First Aid) as an intervention to improve peer support towards adolescents at risk of suicide and to...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
This article presents a careful review of the literature on violence risk and psychosis and suicide risk and psychosis as it...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
We report the case of a child boy 1O years, admitted to our training multiple exostosis, with a location iliopubic left that proved by painful induration left of the base of the penis. Induration the increasing volume, it bothered the child during urination. Conventional radiography and CT were in favor of a pedunculated osteochondroma of the left iliac ramus compressing the urethra. The child underwent surgical tumor resection and pathological examination confirmed the diagnosis of osteochondroma. The evolution was good with disappearance of urinary symptoms down two years without recurrence.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
More News: Adderall | ADHD | Astrocytoma | Brain | Brain Tumor | Cancer & Oncology | Children | Concerta | Depression | Glioma | Hypersomnia | Idiopathic Hypersomnia | Medical Ethics | Methylphenidate | Modafinil | Narcolepsy | Neurology | Provigil | Radiography | Ritalin | Sleep Disorders | Sleep Medicine | Suicide