Heterogeneous brain FDG-PET metabolic patterns in patients with C9orf72 mutation

ConclusionsThe present work is the first in vivo FDG-PET study showing the heterogeneous patterns of brain regional hypo- and hypermetabolism in single patients sharing C9orf72 mutation. Brain hypometabolism was consistent with the clinical phenotypes, supporting the diagnostic importance of neuroimaging functional biomarkers to capture at single-subject level specific brain dysfunction.

http://link.springer.com/10.1007/s10072-018-3685-7

Source: Neurological Sciences - December 15, 2018 Category: Neurology Source Type: research