Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi

ConclusionsGlobal transcriptomic and proteomic profiling of healthy and NASH livers revealed the molecular signatures of diet-induced NASH and dysregulation of the liver secretome. Our study illustrates a novel pathogenic mechanism through which elevated TSK in circulation promotes NASH pathologies, thereby revealing a potential target for therapeutic intervention.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research