Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain

This study validates the proof of concept that the endonuclease domain of Arenavirus can be used as a target for anti-arena-viral drug discovery and that both diketo acids and N-hydroxyisoquinoline-1,3-diones can be considered further as potential metal-chelating pharmacophores.
Source: Antiviral Therapy - Category: Virology Source Type: research