Cytotoxic butenolides and diphenyl ethers from the endophytic fungus Pestalotiopsis sp.

Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Beiye Yang, Qingyi Tong, Shuang Lin, Jieru Guo, Jinwen Zhang, Junjun Liu, Jianping Wang, Hucheng Zhu, Zhengxi Hu, Yonghui ZhangAbstractChemical investigation of the plant endophytic fungus Pestalotiopsis sp. afforded two new butenolides, pestalolides B and C (1 and 2), two new diphenyl ethers, pestalotethers E and F (3 and 4), together with seven known compounds (5–11). Their structures were established by extensive spectroscopic analyses and the absolute configuration of 1 was further confirmed by ECD calculation. Structurally, compound 1 represents the first example of a new type of butenolide derivatives, bearing an unprecedented carbon scaffold having 13 carbon atoms. Compounds 1–4 were evaluated for the cytotoxic activities, and compound 1 showed remarkable inhibitory potency against human tumor HL60, U87MG, MDA-MB-231, and HEP-3B cell lines, with IC50 values of 1.42, 5.90, 5.90, and 4.29 μM, respectively.Graphical abstract

Source: Phytochemistry Letters - December 15, 2018 Category: Chemistry Source Type: research