Infertility patients with chromosome inversions are not susceptible to an inter-chromosomal effect

ConclusionsCarriers of balanced chromosome inversions did not exhibit higher aneuploidy rates for chromosomes that were not involved in the inversion compared to maternal age-matched controls, signifying the absence of an inter-chromosomal effect for this data set. These results provide the largest investigation of blastocyst embryos regarding the debated existence of an ICE resulting from the presence of an inversion during meiosis. However, further studies are warranted to investigate an ICE among inversions subtypes that were outside the scope of this study.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research