Generation of 3 human induced pluripotent stem cell lines LUMCi005-A, B and C from a Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch type patient

Publication date: Available online 14 December 2018Source: Stem Cell ResearchAuthor(s): Elena Daoutsali, Ronald A.M. Buijsen, Simone van de Pas, Anke't Jong, Harald Mikkers, Tom Brands, Bert Eussen, Annelies de Klein, Linda M. van der Graaf, Barry A. Pepers, Christian Freund, Gisela M. Terwindt, Valeria Orlova, Willeke M.C. van Roon-MomAbstractHereditary Cerebral Hemorrhage with Amyloidosis-Dutch type (HCHWA-D) is an autosomal dominant hereditary disease caused by a point mutation in exon 17 of the APP gene. We generated human induced pluripotent stem cells (hiPSCs) from a symptomatic HCHWA-D patient by using non-integrating Sendai virus (SeV). The newly generated hiPSCs express all pluripotency markers, have a normal karyotype, carry the Dutch mutation, can differentiate in the three germ layers in vitro and are SeV free.
Source: Stem Cell Research - Category: Stem Cells Source Type: research