Bromodomain PHD ‑finger transcription factor promotes glioma progression and indicates poor prognosis.

Bromodomain PHD‑finger transcription factor promotes glioma progression and indicates poor prognosis. Oncol Rep. 2018 Oct 30;: Authors: Pan Y, Yuan F, Li Y, Wang G, Lin Z, Chen L Abstract Glioma is one of the most deadly central nervous system tumors around the world. Uncontrollable cell proliferation and invasion are key factors of cancer progression as well as glioma. Available evidence suggests that bromodomain PHD‑finger transcription factor (BPTF) plays an important role in stem cell proliferation and differentiation, as well as in progression of some tumors, but there is little data on glioma. Therefore, the present study aimed to explore the functional role and potential clinical value of BPTF in glioma. Public database, real‑time PCR and western blotting were used to detect the expression of BPTF in glioma tissue and cells. The relationship between BPTF with clinicopathological features and the prognosis of glioma patients was analyzed by immunohistochemical staining in 113 cases of paraffin‑embedded primary glioma specimens. Furthermore, cytological experiments were conducted to elucidate the functional role of BPTF in glioma U251 cells, as well as the potential molecular mechanism. The expression of BPTF in glioma tissues was significantly higher than that in normal brain tissues. The association analysis results revealed that high BPTF expression was significantly associated with WHO grade and tumor size. Survival...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research