Brief Report: Challenging Behaviors in Toddlers and Preschoolers with Angelman, Prader-Willi, and Williams Syndromes.

We examined challenging behaviors in 86 toddlers and preschoolers across three NGS [Angelman syndrome (AS), Prader-Willi syndrome (PWS), and Williams syndrome (WS)] and 43 low-risk controls (LRC), using the Child Behavior Checklist for Ages 1½-5. Challenging behavior profiles differed across NGS, with generally elevated behaviors in AS and WS, but not PWS, relative to LRC. Withdrawn and autism spectrum symptoms were particularly elevated in AS. Although several profiles were similar to those previously reported in older children and adults, we also observed inconsistencies that suggest non-linear developmental patterns of challenging behaviors. These findings underscore the importance of characterizing early challenging behaviors to inform atypical phenotypic development and targeted intervention. PMID: 30542941 [PubMed - as supplied by publisher]
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research

Related Links:

During the past five decades, Temple Grandin's visually indexed mind, a key feature of her autism, helped make her a leading animal researcher.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Singer EV, Shelton AR, Malow BA. Can we predict which children with autism will have obstructive sleep apnea?J Clin Sleep Med. 2019;15(10):1389–1390.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Conclusions:The absence of demographic or clinical predictors of OSA supports using general indications for PSG in children with ASD.Citation:Tomkies A, Johnson RF, Shah G, Caraballo M, Evans P, Mitchell RB. Obstructive sleep apnea in children with autism.J Clin Sleep Med. 2019;15(10):1469–1476.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
ConclusionsAll patients with severe autism had SPAs. However, they did not correlate with FDG-PET findings.
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
Stephanie Nimmo, 51, from South-West London, is aware that, by speaking out in favour of vaccinations, she will be hit by a furious backlash from the anti-vax community.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
One in every 59 children born in the United States will develop autism. Yet much of the biology behind the disorder remains unknown. That may soon change thanks to a $20 million gift from Wall Street investment banker K. Lisa Yang and her husband, Broadcom CEO Hock E. Tan, to Harvard University, which will bring together scientists and researchers in a new Center for Autism Research to better understand the underpinnings of the disease.  “The crux of our center is to have input from people in…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
The ability of resting-state functional MRI (fMRI) to pinpoint reduced brain...Read more on AuntMinnie.comRelated Reading: fMRI connects words to brain activity fMRI may speed up diagnosis of autism fMRI links imaging biomarker to PTSD treatment response PET, fMRI shed light on alcohol's effects on brain Machine learning, fMRI unlock cellular brain properties
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
AbstractIn humans, variations in the polysialic acid ‐producing enzyme ST8SIA2 and disturbances in the cortical inhibitory system are associated with neurodevelopmental psychiatric disorderssuch as schizophrenia and autism. In mice, the ST8SIA2‐dependent formation of polysialic acid during embryonic development is crucial for the establishment of interneuron populations of the medial prefrontal cortex (mPFC). However, the spatial pattern and the neurodevelopmental mechanisms of interneuron changes caused by loss of ST8SIA2 functionhave not been fully characterized. Here, we use immunohistochemical analysis to demonstra...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: Original Article Source Type: research
.
Source: Journal of Clinical Child and Adolescent Psychology - Category: Psychiatry & Psychology Authors: Source Type: research
CONCLUSIONS: Our findings suggest the necessity of CMA as a routine diagnostic test for unexplained DD, MR, and ASD in Korea. PMID: 26206688 [PubMed - in process]
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
More News: Angelman Syndrome | Autism | Brain | Child Development | Children | Neurology | Prader-Willi Syndrome | Psychiatry | Williams Syndrome