In vitro removal of anti-infective agents by a novel cytokine adsorbent system.

CONCLUSION:: In these settings, all tested drugs were adsorbed by the cartridge in relevant amounts. The identified maximum adsorptive capacity and the rapid decline in concentration during the first 1.5 h of CytoSorb use suggest that the administration of an additional dose within the first hours of CytoSorb treatment may be reasonable. In addition, early therapeutic drug monitoring should be considered.
PMID: 30545255 [PubMed - as supplied by publisher]

Source: The International Journal of Artificial Organs - December 13, 2018 Category: Transplant Surgery Authors: König C, Röhr AC, Frey OR, Brinkmann A, Roberts JA, Wichmann D, Braune S, Kluge S, Nierhaus A Tags: Int J Artif Organs Source Type: research