Translating preventive chemotherapy prevalence thresholds for < i > Schistosoma mansoni < /i > from the Kato-Katz technique into the point-of-care circulating cathodic antigen diagnostic test

Conclusions/significanceThe moderate sensitivity of POC-CCA, even for very lightS. mansoni infections where the sensitivity of Kato-Katz is very low, and the identified relationship between Kato-Katz and POC-CCA prevalence thresholds render the latter diagnostic tool useful for surveillance and initial estimation of elimination ofS. mansoni. For prevalence below 10% based on a duplicate slide Kato-Katz thick smear, we suggest using POC-CCA including trace results to evaluate treatment needs and propose new intervention thresholds that need to be validated in different settings.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research