Supplementation with Beta-Hydroxy-Beta-Methylbutyrate Impacts Glucose Homeostasis and Increases Liver Size in Trained Mice.

Supplementation with Beta-Hydroxy-Beta-Methylbutyrate Impacts Glucose Homeostasis and Increases Liver Size in Trained Mice. Int J Vitam Nutr Res. 2018 Dec 14;:1-10 Authors: Schadock I, Freitas BG, Moreira IL, Rincon JA, Nunes Correa M, Zanella R, Sampaio Silva E, Carvalho Araujo R, Buchweitz MRD, Helbig E, Del Vecchio FB, Schneider A, Castilho Barros C Abstract β-hydroxy-β-methyl butyrate (HMB) is a bioactive metabolite derived from the amino acid leucine, usually applied for muscle mass increase during physical training, as well as for muscle mass maintenance in debilitating chronic diseases. The hypothesis of the present study is that HMB is a safe supplement for muscle mass gain by strength training. Based on this, the objective was to measure changes in body composition, glucose homeostasis and hepatic metabolism of HMB supplemented mice during strength training. Two of four groups of male mice (n =6 /group) underwent an 8-week training period (climbing stairs) with or without HMB supplementation (190 mg/kgBW per day). We observed lower body mass gain (4.9 ± 0.43% versus 1.2 ± 0.43, p <0 .001) and increased liver mass (40.9 ± 0.9 mg/gBW versus 44.8 ± 0.3, p < .001) in the supplemented trained group compared with the non-supplemented groups. The supplemented trained group had an increase in relative adipose tissue mass (12.4 ± 0.63 mg/gBW versus 16.1 ± 0.88, p<0.01) compared to the non-supplemented untrained group...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research