Alzheimer peripheral blood: mRNA expression of amyloid precursor protein cleaving enzyme

(Bentham Science Publishers) Alzheimer's disease (AD) is the most common cause of dementia in elderly populations. Changes in the expression of the amyloid precursor protein (APP)-cleaving enzymes directly affect the formation of amyloid beta (Aβ) plaques, a neuropathological hallmark of AD.BACE1 mRNA level in AD subjects was significantly higher than those of healthy controls, whereas ADAM10 level was significantly lower in the AD subjects.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news