Evaluation of Healthy User Effect in Metformin and Other Oral Anti Hyperglycemic Medications Users among Adult Type 2 Diabetes Patients

ConclusionsOur results suggest that metformin users are more likely to initiate preventive therapies and engage in other healthy behaviors. Failure to account for these behaviours may introduce healthy user bias into studies evaluating the effect of oral antidiabetic therapies.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research

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CONCLUSION: LSS using three time-point (C1, C4, and C8) provides the most reliable and accurate simultaneous estimation of the AUC0-12 of MPA and AcMPAG in Japanese lung transplant patients. PMID: 31430249 [PubMed - in process]
Source: J Pharm Pharm Sci - Category: Drugs & Pharmacology Authors: Tags: J Pharm Pharm Sci Source Type: research
Gu et  al. (AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science. 2019;363:1085–1088, https://doi.org/10.1126/science.aav1749)
Source: Kidney International - Category: Urology & Nephrology Tags: Journal Club Source Type: research
Although control of chronic glycemia in the population with diabetes and end-stage renal disease (ESRD) has been extensively studied in recent years, the unique problems of short-term glycemic management in acutely ill patients undergoing dialysis have received little attention. Bally et  al. evaluated the role of a “closed-loop” (glucose sensor/algorithm tablet device/insulin pump) system in a cohort of hospitalized patients with type 2 diabetes receiving hemodialysis. Compared with usual care, the intervention group had superior glycemic control without increased hypoglycemic events.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
An 82-year-old male, with a history of bowel cancer with partial colectomy, gastroesophageal reflux disease, remote partial gastrectomy for peptic ulcer disease, and no documented prior kidney disease, presents with several months of fatigue and subacute decline in kidney function. He had no history of diabetes, hypertension, kidney stones, or prior urinary tract infections. He denied use of nonsteroidal anti-inflammatory agents, herbal medications, and recent antibiotics. There was no family history of renal disease.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
The purpose of this study was to explore the experiences and perspectives of leisure constraints among lesbian women who attended a straight-friendly (LGBTQ-focused) church in Eastern Canada. Seven lesbians completed individual interviews, which were digit...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Recreational and Sports Issues Source Type: news
Authors: Carretero-Anibarro E, Hamud-Uedha M PMID: 31427152 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
CONCLUSIONS: Dapagliflozin, in subjects with DM2, produces a medium to long-term decrease in arterial stiffness. PMID: 31420083 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
We read with great interest the study by O'Donnell et  al,1 which investigated the risk factors of postoperative renal dysfunction after open repair of abdominal aortic aneurysm (AAA) in a large retrospective cohort.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
We thank Drs Yoon and Kim for their interest in our study and the higher risk for acute kidney injury (AKI) after open repair of juxtarenal abdominal aortic aneurysms in patients taking statins preoperatively. Our understanding of the interaction between statins and postoperative renal function is constantly evolving, as both observational and randomized trials have met with mixed results. Importantly, previous studies showed that initiating statins in the perioperative period was associated with higher rates of postoperative AKI, whereas long-term statin use was associated with lower risk of renal complications.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
The Wound Ischemia foot Infection (WIfI) classification has gained widespread acceptance in the vascular community as a method of categorizing disease severity in patients with chronic limb-threatening ischemia (CLTI). The original WIfI system is based on a Delphi consensus model, which relies on an iterative process of consensus amongst experts, but is not necessarily data driven. Twelve experts were selected in the formation of the initial WIfI model. The WIfI classification was initially developed in a cohort of CLTI patients not undergoing revascularization, but since then has been extrapolated to predict outcomes of m...
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Clinical research study Source Type: research
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