The −44 C/G (rs1800972) polymorphism of the β‐defensin 1 is associated with increased risk of developing type 2 diabetes mellitus

ConclusionThis study demonstrates that the C allele of −44 C/G polymorphism, as well as haplotype AC are associated with the presence of T2DM in the Mexican population. The variation in this polymorphism of theDEFB1 gene could increase the migration of the macrophages to pancreatic islets accelerate the β‐cell dysfunction in T2DM.

Source: Molecular Genetics & Genomic Medicine - December 13, 2018 Category: Genetics & Stem Cells Authors: Marco Antonio Martinez ‐Rios, Gilberto Vargas‐Alarcon, Marco Antonio Peña‐Duque, Oscar Perez‐Mendez, Jose Manuel Rodriguez‐Perez, Nonanzit Perez‐Hernandez, Gabriel Herrera‐Maya, Rosalinda Posadas‐Sanchez, Carlos Posadas‐Romero, Tags: ORIGINAL ARTICLE Source Type: research