Estimating State-Level Health Burden of Diabetes: Diabetes-Attributable Fractions for Diabetes Complications
ConclusionsDiabetes carries a significant health burden, and results vary across states. Efforts to prevent or delay diabetes or to improve diabetes management could reduce the health burden because of diabetes.
ConclusionsA clinically relevant model of PTA of venous stenosis in mice was created. PTA-treated vessels had increased lumen vessel area and WSS. The alterations in tissue markers of vascular remodeling, tissue hypoxia, proliferation, and cell death may be implications for future design of drug and device development.
Publication date: Available online 28 February 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Sadikah Behbehani, Tiffany Pham, Katie Kunze, Megan Wasson, Johnny YiABSTRACTStudy ObjectiveTo determine the incidence of a successful in-office voiding trial after minimally invasive hysterectomy.DesignA retrospective cohort study.SettingA tertiary care academic center.PatientsAll patients undergoing minimally invasive hysterectomies (vaginal, laparoscopic, or robotic) from January 2013 to July 2018 who have an unsuccessful voiding trial in the postoperative unit.InterventionsA voiding trial.Measurements and Main ...
While rare, more than 90% of people who suffer a SCAD heart attack are women, and it’s responsible for 40% of heart attacks in women under the age of 50.
Authors: Medrano Navarro AL, Justel Enríquez A, Alameda Serrano J, Blasco Lamarca Y, Sáenz Abad D, Gimeno Orna JA Abstract BACKGROUND AND AIMS: Our aim was to assess the usefulness of KDIGO 2012 risk classification to predict total and cardiovascular mortality in type 2 diabetes mellitus (DM2). MATERIAL AND METHODS: Prospective cohort study that included DM2 patients. Clinical end-points were total and cardiovascular mortality. The main predictive variable was KDIGO risk classification, which is a combination of urinary albumin excretion and glomerular filtration rate. The predictive value was eva...
Conclusions: POAG cases and controls had similar neurocognitive function as measured by the MoCA. Among POAG cases, worse VF loss was associated with lower MoCA. Future studies are needed to further elucidate the clinical effect of neuropathy in POAG.Neurodegener Dis 2018;18:315 –321
In this study, a candidate gene prioritization method was proposed for non-communicable diseases considering disease risks transferred between genes in weighted disease PPI networks with weights for nodes and edges based on functional information. Here, three types of non-communicable diseases with pathobiological similarity, Type 2 diabetes (T2D), coronary artery disease (CAD) and dilated cardiomyopathy (DCM), were used as case studies. Literature review and pathway enrichment analysis of top-ranked genes demonstrated the effectiveness of our method. Better performance was achieved after comparing our method with other ex...
We describe a case in a 72-year-old Caucasian man with long-term HIV infection. We observed the development of unbalanced diabetes treated with insulin and metformin which improved when we replaced zidovudine with rilpivirine. This switch improved diabetes to such an extent that insulin suspension was required. In several countries zidovudine has long been used due to its low cost, although several side effects have been observed, especially in the long term. In this case, the switch to rilpivirine was shown to be able to improve the toxicity of zidovudine on glucose metabolism, representing a good option to be used. P...
Conclusion: The rate of SAEs associated with (not necessarily caused by) diazoxide has been demonstrated. The rate of SAE in newborns with perinatal stress hyperinsulinism is significantly higher than that of otherwise healthy babies with genetic forms of hyperinsulinism, suggesting that caution should be used when prescribing diazoxide to this population. This information should help balance the risk benefit of treatment and provide guidance on screening for these complications in the population of treated patients.Horm Res Paediatr
Publication date: Available online 19 March 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Xuequan Zhu, Yue Gao, Amy Gillespie, Ying Xin, Ji Qi, Jianjun Ou, Shaoling Zhong, Ke Peng, Tingting Tan, Chaoyue Wang, Runsen Chen
ConclusionsOur results reveal mechanistic details of how common coding mutations in PDX1 impair human pancreatic endocrine lineage formation and β-cell function and contribute to predisposition for diabetes.
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