MiR-543 promotes cell proliferation and metastasis of renal cell carcinoma by targeting Dickkopf 1 through the Wnt/ β -catenin signaling pathway

Conclusion: Our study indicated that miR-543 negatively regulate the expression of DKK-1 in vitro. MiR-543 promotes malignancy phenotypes of RCC both in vitro and in vivo. This regulatory effect of miR-543 may be associated with Wnt/β-catenin signaling pathway. Therefore, miR-543 could be used as a biomarker for predicting the progression of RCC.

Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Zhi-yuan Chen, Yang Du, Lei Wang, Xiu-heng Liu, Jia Guo, Xiao-dong Weng Tags: Research Paper Source Type: research