Long Non-coding RNA LINC01234 Regulates Proliferation, Invasion and Apoptosis in Esophageal Cancer Cells

The objective of the study was to investigate the expression and role of LINC01234 in progression of esophageal cancer cells. LncRNA LINC01234 was found to be upregulated in esophageal cancer cells by chip sequencing. The expression level of LINC01234 was detected from different esophageal cancer cell lines by qRT-PCR. After this, the LINC01234 knockdown effects on cell proliferation, migration, invasion, and apoptosis were evaluated by cell proliferation assay, wound healing assay, invasion assay, and flow cytometric analysis in vitro. Expression of lncRNA LINC01234 was found to be markedly upregulated in the CEC2 cell line. Furthermore, cell proliferation, migration and invasion were significantly (P
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research

Related Links:

ConclusionCC shows an indolent clinical behavior, with a low recurrence rate after radical surgery. The diagnosis of this rare tumor is typically made after surgery. An aggressive approach is required with curative intents.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Conclusions53BP1-NF accumulation increases during cancer progression from LG-IN to HG-IN to CIS to SCC. Detection of 53BP1-NF by immunofluorescence, especially large foci, is a feasible method of estimating DNA instability and the malignant potential of esophageal intraepithelial neoplasia.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
November 23-24, 2019
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Announcement Source Type: research
Esophageal cancer is a highly lethal disease, especially in developing countries. China has been a high-incidence area of esophageal cancer for many years and accounts for over 50% of the global morbidity and mortality [1]. The two major histological types of esophageal cancer are squamous cell carcinoma (ESCC) and adenocarcinoma, and there is a striking geographical variation in the incidence of the esophageal cancer subtypes. In China, approximately 90% of patients with esophageal cancer are diagnosed with ESCC [2].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Proton therapy has an important role in the management of head and neck cancer, where the dosimetric characteristics of proton particles are advantageous for treating tumors in complex anatomic areas. In addition to highly targeted dose depositions owing to the Bragg peak and superior lateral dose distribution of proton therapy, the introduction of spot-scanning techniques that allow intensity-modulated proton therapy (IMPT) further improve dose distributions and normal-tissue sparing relative to intensity-modulated (photon) radiation therapy (IMRT), a finding that has been validated in case-matched analyses showing lower ...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Oesophageal cancer is a malignancy with a poor prognosis, as reflected by an average overall 5-year survival of only 18% [1]. Locally advanced oesophageal cancer patients are generally treated by chemo- and/or radiotherapy, either as definite treatment or as neoadjuvant treatment prior to surgery [2 –4]. However, not all patients benefit equally. In 23% of adenocarcinomas (AC) and 49% of squamous cell carcinomas (SCC) a pathological complete response (pCR, tumour regression grade (TRG) 1) is determined on histopathology of the resection specimen after neoadjuvant chemoradiotherapy (nCRT) [2,5 ].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Systematic Review Source Type: research
Esophageal cancer incidence in the Western world has risen over the past decades, with adenocarcinomas now being more prevalent than squamous cell carcinomas [1]. Alcohol intake, tobacco smoking and overweight are key risk factors, especially for adenocarcinomas. The disease is rarely curable with a 5-year overall survival of approximately 20% [2,3]. Standard treatment consists of neoadjuvant chemoradiotherapy followed by surgery [4].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Authors: Hao J, Li S, Li J, Jiang Z, Ghaffar M, Wang M, Jia R, Chen S, Wang Y, Zeng Y Abstract Esophageal carcinoma (EC) is the sixth most deadly of all cancers. It is among the most malignant cancers due to its highly aggressive nature and low survival rate. The incidence of EC is high in Asia, particularly in Southern areas including China, Iran and Japan. There is a large body of evidence to suggest an association between the melanoma antigen gene (MAGE) family and the initiation of cancer; however, there is no clear evidence to suggest an association between EC and MAGE. Discovery of the chemical and physiologi...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Fan Y, Wang Y, Fu S, Liu D, Lin S Abstract The Krüppel-associated box zinc-finger protein 545 (ZNF545) was recently identified as a tumor suppressor in esophageal squamous cell carcinoma (ESCC). However, the role of ZNF545 in the tumorigenesis of esophageal cancer cells expressing loss-of-function mutant p53 has not been elucidated. In the present study, the role of ZNF545 in esophageal tumors and the p53-mutant ESCC cell line, KYSE150, was investigated. ZNF545 mRNA was significantly downregulated in tumors when compared with adjacent normal tissues. Methylated ZNF545 was detected in 76.6% of tumor ti...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Morphological lymphocytic reaction, patient prognosis and PD-1 expression after surgical resection for oesophageal cancer. Br J Surg. 2019 Sep;106(10):1352-1361 Authors: Baba Y, Yagi T, Kosumi K, Okadome K, Nomoto D, Eto K, Hiyoshi Y, Nagai Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Komohara Y, Watanabe M, Baba H Abstract BACKGROUND: Immune checkpoint inhibitors, such as antibody against programmed cell death protein (PD-1), have demonstrated antitumour effects in patients with malignancies, including oesophageal cancer. A lymphocytic reaction observed by pathological examinatio...
Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
More News: Cancer | Cancer & Oncology | Esophagus Cancer | Study