Distinct Changes in the Expression TAZ are Associated with Normal Cervix and Human Cervical Cancer

In this study, we examined the TAZ protein expression and cellular localization in 194 cases of human cervical squamous cell carcinoma (SCC). We observed that a normal cervix is characterized by higher expression levels of both nuclear and cytosolic TAZ compared to cervical SCC. Lower membranous and cytosolic TAZ expression levels are associated with lymph node involvement. We observed that TAZ expression levels are associated with β1 integrin and Src in SCC and cell lines derived from human cervical cancers. Of note, knock down of TAZ increased the expression of β1 integrin and Src in both normal and human cervical cancer cells. Our data indicate that the expression and cellular localization of TAZ are inversely associated with the development and progression of cervical SCC, and TAZ-mediated transcription may be involved in the activation of the integrin-Src signalling pathway.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research

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Authors: Razia S, Nakayama K, Nakamura K, Ishibashi T, Ishikawa M, Minamoto T, Iida K, Otsuki Y, Nakayama S, Ishikawa N, Kyo S Abstract The aim of the present study was to evaluate the mutation and amplification status of the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) gene, as well as the association with clinicopathological characteristics and prognosis, in Japanese patients with cervical cancer. Fluorescence in situ hybridization and polymerase chain reaction were performed to assess PIK3CA gene amplification and mutation. The inhibitors temsirolimus and NVP-BEZ235 were used...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
At present, the standard treatment approach for locally advanced cervical cancer is concurrent chemoradiotherapy (CCRT). An elevated pretreatment squamous cell carcinoma antigen (SCC Ag) level is associated wi...
Source: Radiation Oncology - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Authors: Chen L, Wang X, Song L, Yao D, Tang Q, Zhou J Abstract The diagnosis and treatment of cervical squamous cell carcinoma is challenged by difficulties in the determination of tumor invasion. GATA binding protein 6 antisense (GATA6-AS) is a recently identified long non-coding RNA that exhibits critical functions in the growth of endothelial cells; however, to the best of our knowledge, its involvement in other physiological and pathological processes is unknown. By reverse transcription-quantitative polymerase chain reaction, the present study examined the expression of GATA6-AS in tumor tissues and adjacent ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Introduction: Definitive chemoradiotherapy (CRT) followed by high-dose-rate (HDR) brachytherapy (BT) is the state-of-the-art treatment for locally advanced (≥ FIGO IIb) cervical cancer but three-year survival rates are stagnating in recent years indicating the need for biomarker development and patient’s stratification. In the present study we aimed to analyse the predictive relevance of Polo-like kinase (PLK) 3 expression and levels of Caspase 8 T273 phosphorylation in patients with advanced cervical squamous cell carcinoma (CSCC) treated with CRT and BT. Methods: In a cohort of 74 patients with FIGO Stage Ib...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
This study aimed to explore the role of SRA1 in cervical squamous cell carcinoma (CSCC). In the present study we showed that plasma SRA1 was downregulated in HPV-negative CSCC patients but not in HPV-positive CSCC patients comparing to healthy females. Downregulated SRA1 distinguished HPV-negative CSCC patients from HPV-positive CSCC patient and healthy females. In HPV-negative CSCC patients, miR-9 was upregulated and inversely correlated with SRA1. In HPV-negative CSCC cells, SRA1 overexpression caused the downregulated miR-9, while miR-9 overexpression failed to affect SRA1. Moreover, SRA1 overexpression caused decreased...
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research
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Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Tags: Cancer Biol Ther Source Type: research
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Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
We report the first case of intramedullary metastasis affecting the thoracic spinal cord from esophageal squamous cell carcinoma in a 35-year-old patient.
Source: Journal of Radiology Case Reports - Category: Radiology Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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