The Clinical and Biomarker Association of Programmed Death Ligand 1 and its Spatial Heterogeneous Expression in Colorectal Cancer

Conclusions: PD-L1 expression was a marker of pre-existing immune responses in colorectal cancer, however, it was heterogeneously expressed in colorectal cancer, especially between primary and metastatic tumors. This might partially explain the low-efficiency of its predictive value for benefit from anti-PD-1 treatment.

Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xiao-Li Wei, Qi-Nian Wu, Dong-liang Chen, Zhao-Lei Zeng, Jia-Bin Lu, Ze-Xian Liu, Huai-Qiang Ju, Chao Ren, Zhi-Zhong Pan, Feng-Hua Wang, Rui-Hua Xu Tags: Research Paper Source Type: research