PD-1 Blockade Overcomes Adaptive Immune Resistance in Treatment with Anchored-GM-CSF Bladder Cancer Cells Vaccine

Conclusions: Anchored-GM-CSF vaccines and anti-PD-1 antibodies have synergistic effects in metastatic bladder cancer treatment. PD-1 blockade can overcome immune resistance in treatment with the Anchored-GM-CSF vaccine, while Anchored-GM-CSF vaccine can enhance the efficacy of PD-1 blockade therapy.

http://www.jcancer.org/v09p4374.htm

Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Xinji Zhang, Xiaojun Shi, Jinlong Li, Lijun Mo, Zhiming Hu, Jimin Gao, Shihao Wu, Zhaolin Long Tags: Research Paper Source Type: research