Tenascin-C Modulates Cell Cycle Progression to Enhance Tumour Cell Proliferation through AKT/FOXO1 Signalling in Pancreatic Cancer

In conclusion, TNC exerts its activating effect on the proliferation of pancreatic cancer cells in vitro and in vivo through its functional target AKT/FOXO1/β-catenin. The molecular mechanisms that drive PDAC progression will be useful for the development of molecular markers and the evaluation of patient prognosis.

Source: Journal of Cancer - December 14, 2018 Category: Cancer & Oncology Authors: Jun Cai, Wenli Lu, Shaoxia Du, Zhongkui Guo, Hui Wang, Wei Wei, Xiaohong Shen Tags: Research Paper Source Type: research