The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone

AbstractZiprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could attenuate peripheral inflammatory and oxidative stress potentially triggered ZIP. This is the case of guaran á xanthine-catechin chemical matrix (XC-Mix) that presents caffeine, theobromine, and catechin. Thein vitro protocols using murine RAW 264.7 cell macrophages were ZIP-exposure in culture medium supplemented with chemical isolated and admixture of Caf, The, and Cat. Main results showed that supplementation with isolated and XC-mix had a lowering effect on 72  h macrophages proliferation. XC-mix with 1:1:1 proportion at 25 μg/mL of each caffeine, theobromine, and catechin, molecules present lowering effect on nitric oxide levels, oxidative stress markers (DNA oxidation quantified by 8-hydroxy-2′ –deoxyguanosine), lipoperoxidation, and protein carb onylation. XC-mix also decreased protein levels and downregulated genes of proinflammatory cytokines (IL-1β, IL-6, TNF-α). At contrary, XC-Mix increased levels and upregulated gene of anti-inflammatory IL-10 cytokine. The results suggest that XC-matrix could present some beneficial action on perip heral proinflammatory effects ZIP-triggered. Complementaryin vivo stud...
Source: Inflammation - Category: Allergy & Immunology Source Type: research

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Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
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Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
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Source: Neuropsychologia - Category: Neurology Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
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Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
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