The Influence of a Xanthine-Catechin Chemical Matrix on in vitro Macrophage-Activation Triggered by Antipsychotic Ziprasidone
AbstractZiprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could attenuate peripheral inflammatory and oxidative stress potentially triggered ZIP. This is the case of guaran á xanthine-catechin chemical matrix (XC-Mix) that presents caffeine, theobromine, and catechin. Thein vitro protocols using murine RAW 264.7 cell macrophages were ZIP-exposure in culture medium supplemented with chemical isolated and admixture of Caf, The, and Cat. Main results showed that supplementation with isolated and XC-mix had a lowering effect on 72 h macrophages proliferation. XC-mix with 1:1:1 proportion at 25 μg/mL of each caffeine, theobromine, and catechin, molecules present lowering effect on nitric oxide levels, oxidative stress markers (DNA oxidation quantified by 8-hydroxy-2′ –deoxyguanosine), lipoperoxidation, and protein carb onylation. XC-mix also decreased protein levels and downregulated genes of proinflammatory cytokines (IL-1β, IL-6, TNF-α). At contrary, XC-Mix increased levels and upregulated gene of anti-inflammatory IL-10 cytokine. The results suggest that XC-matrix could present some beneficial action on perip heral proinflammatory effects ZIP-triggered. Complementaryin vivo stud...
Conclusions: Although persons with AD are often collectively considered as expensive patient group, there is large temporal and inter-individual variation in belonging to the highest decile of hospitalization and/or medication costs. It would be important to assess whether hospitalization rate could be decreased by, e.g., comprehensive outpatient care with more efficient management of comorbidities. In addition, other interventions that could decrease hospitalization rate in persons with dementia should be studied further in this context. Key messages Persons with AD had large individual fluctuation in hospital care costs ...
Conclusion and Significance: Understanding the participants' lived experiences raised consciousness of the injustices that exist before and during rehabilitation which uncovered pointers to improve local substance addiction rehabilitation programs: use of occupation-based social participation interventions, limitation of occupational therapy services due to lack of human resources reinforcing interprofessional collaboration, a participatory approach is essential in discussing and addressing injustices, and deliberate use of political activities of daily living. PMID: 31322976 [PubMed - as supplied by publisher]
Publication date: August 2019Source: Neuropsychologia, Volume 131Author(s):
ConclusionDespite the use of AEDs in the majority of patients, only one-third were seizure-free. Other challenges included polypharmacy, the use of valproate in women, and variable adherence. This points to a need for closer follow-up in patients with JME.Graphical abstract
POLLEN COUNT for most parts of the UK have been forecasted by the Met Office. What is the pollen count for today and how can you better manage your symptoms?
A Pennsylvania school district notified parents, whose children had a meal debt of $10 or more, of the potential consequence but officials said the letter was not sanctioned by the superintendent.
This article reviews targeted therapy treatment options for patients with metastatic BC, including strategies for administration, side effects, and nursing considerations. PMID: 31322617 [PubMed - in process]
Chief medical correspondent Dr. Jon LaPook joined "CBS Weekend News" to discuss how to stay ahead of the symptoms that contributed to the deaths of at least six people
Authors: Plagens-Rotman K, Przybylska R, Gerke K, Jaracz K, Serafinowska J, Sadowska-Przytocka A, Adamski Z, Czarnecka-Operacz M PMID: 31320864 [PubMed]
Authors: Kupryś-Lipińska I, Pałczyński C, Molinska J, Kuna P PMID: 31320863 [PubMed]